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Submit ReviewEndomorphin-2
Discontinued Product
1056 has been discontinued.
Description: Potent and selective μ agonist
Purity: ≥95% (HPLC)
Biological Activity for Endomorphin-2
Endomorphin-2 is a endogenous peptide with extremely high affinity and selectivity for μ-opioid receptors (with Ki values of 0.69, 9233 and 5240 nM for μ, δ and κ respectively).
Technical Data for Endomorphin-2
| M. Wt | 571.65 |
| Formula | C32H37N5O5 |
| Sequence |
YPFF (Modifications: Phe-3 = C-terminal amide) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 141801-26-5 |
| PubChem ID | 5311081 |
| InChI Key | XIJHWXXXIMEHKW-LJWNLINESA-N |
| Smiles | [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Endomorphin-2
References for Endomorphin-2
References are publications that support the biological activity of the product.
Chapman et al (1997) Distinct inhibitory effects of spinal endomorphin-1 and endomorphin-2 on evoked dorsal horn neuronal responses in the rat. Br.J.Pharmacol. 122 1537 PMID: 9422796
Goldberg et al (1998) Pharmacological characterization of endomorphin-1 and endomorphin-2 in mouse brain. J.Pharmacol.Exp.Ther. 286 1007 PMID: 9694962
Harrison et al (1998) Differential effects of endomorphin-1, endomorphin-2, and tyr-W-MIF-1 on activation of G-proteins in SH-SY5Y human neuroblastoma membranes. Peptides 19 749 PMID: 9622031
Zadina et al (1997) A potent and selective endogenous agonist for the μ-opiate receptor. Nature 386 499 PMID: 9087409
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Keywords: Endomorphin-2, Endomorphin-2 supplier, Potent, selective, μ-opioid, mu-opioid, agonists, MOP, Receptors, OP3, Mu, Opioid, 1056, Tocris Bioscience
1 Citation for Endomorphin-2
Citations are publications that use Tocris products. Selected citations for Endomorphin-2 include:
Garzón et al (2004) RGSZ1 and GAIP regulate mu- but not delta-opioid receptors in mouse CNS: role in tachyphylaxis and acute tolerance. Neuropsychopharmacology 29 1091 PMID: 14997173
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