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Enoximone

Cat. No. 1693 Submit a Review Datasheet / COA / SDS
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Description: PDE3 inhibitor
Chemical Name: 1,3-Dihydro-4-methyl-5-[4-(methylthio)benzoyl]-2H-imidazol-2-one
Purity: ≥99% (HPLC)
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Enoximone

Enoximone is an inhibitor of type III phosphodiesterase (PDE3). Increases intracellular cyclic AMP (cAMP) concentrations and enhances myocardial contractility. Also induces concentration-dependent vasodilation in vitro.

Technical Data for Enoximone

M. Wt 248.3
Formula C12H12N2O2S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 77671-31-9
PubChem ID 53708
InChI Key ZJKNESGOIKRXQY-UHFFFAOYSA-N
Smiles CC(NC(N2)=O)=C2C(C1=CC=C(SC)C=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Enoximone

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 24.83 100

Preparing Stock Solutions for Enoximone

The following data is based on the product molecular weight 248.3. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.03 mL 20.14 mL 40.27 mL
5 mM 0.81 mL 4.03 mL 8.05 mL
10 mM 0.4 mL 2.01 mL 4.03 mL
50 mM 0.08 mL 0.4 mL 0.81 mL

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References for Enoximone

References are publications that support the biological activity of the product.

Jung et al (2005) Pharmacological effects of ATI22-107 [2-(2-{2-[2-chloro-4-(6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-phenoxy]-acetylamino}-ethoxymethyl)-4-(2-chloro-phenyl)-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester)], a novel dual pharmacophore, o J.Pharmacol.Exp.Ther. 312 517 PMID: 15550574

Pacher and Stanek (1999) Ambulatory vasodilator therapy in heart failure: systematic review of the literature and personal observational experience. Eur.J.Heart Fail. 1 263 PMID: 10935673

Vroom et al (1996) Effect of phosphodiesterase inhibitors on human arteries in vitro. Br.J.Anaesth. 76 122 PMID: 8672353

If you know of a relevant reference for Enoximone, please let us know.

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Keywords: Enoximone, Enoximone supplier, phosphodiesterases, pde3, pdeIII, inhibitors, inhibits, Phosphodiesterases, 1693, Tocris Bioscience

Citations for Enoximone

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