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Submit ReviewEscitalopram oxalate
Description: Selective serotonin reuptake inhibitor (SSRI)
Chemical Name: (+)-(S)-1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile oxalate
Purity: ≥98% (HPLC)
Biological Activity for Escitalopram oxalate
Escitalopram oxalate is a selective 5-HT reuptake inhibitor (Ki values are 0.89, 8150, and 10500 nM for serotonin, noradrenalin, and dopamine transporters respectively). Escitalopram oxalate is an S-enantiomer and eutomer of citalopram (Cat. No. 1427).
Compound Libraries for Escitalopram oxalate
Escitalopram oxalate is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.
Technical Data for Escitalopram oxalate
| M. Wt | 414.43 |
| Formula | C20H21FN2O.C2H2O4 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 219861-08-2 |
| PubChem ID | 146571 |
| InChI Key | KTGRHKOEFSJQNS-BDQAORGHSA-N |
| Smiles | FC(C=C3)=CC=C3[C@]1(CCCN(C)C)OCC2=C1C=CC(C#N)=C2.OC(C(O)=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Escitalopram oxalate
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 20.72 | 50 | |
| DMSO | 41.44 | 100 |
Preparing Stock Solutions for Escitalopram oxalate
The following data is based on the product molecular weight 414.43. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.41 mL | 12.06 mL | 24.13 mL |
| 5 mM | 0.48 mL | 2.41 mL | 4.83 mL |
| 10 mM | 0.24 mL | 1.21 mL | 2.41 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
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Product Datasheets for Escitalopram oxalate
References for Escitalopram oxalate
References are publications that support the biological activity of the product.
Zhang et al (2010) Structure-activity relationships for a novel series of cital. (1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile) analogues at monoamine transporters. J.Med.Chem. 53 6112 PMID: 20672825
If you know of a relevant reference for Escitalopram oxalate, please let us know.
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Keywords: Escitalopram oxalate, Escitalopram oxalate supplier, Selective, serotonin, reuptake, inhibitors, inhibits, SSRI, SERT, 5-HT, Transporters, 4796, Tocris Bioscience
4 Citations for Escitalopram oxalate
Citations are publications that use Tocris products. Selected citations for Escitalopram oxalate include:
William C et al (2021) Psychedelic-inspired drug discovery using an engineered biosensor. Cell 184 2779-2792.e18 PMID: 33915107
Il-Whan et al (2017) Escitalopram, a selective serotonin reuptake inhibitor, inhibits voltage-dependent K+ channels in coronary arterial smooth muscle cells. Korean J Physiol Pharmacol 21 415-421 PMID: 28706455
Lu et al (2016) Generation of serotonin neurons from human pluripotent stem cells. J Exp Med 34 89 PMID: 26655496
Henry A et al (2020) Directed Evolution of a Selective and Sensitive Serotonin Sensor via Machine Learning. Cell 183 1986-2002.e26 PMID: 33333022
Do you know of a great paper that uses Escitalopram oxalate from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.