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Submit ReviewEtodolac
Description: Selective cyclooxygenase-2 (COX-2) inhibitor; NSAID
Chemical Name: (RS)-2-(1,8-Diethyl-4,9-dihydro-3H-pyrano[3,4-b]indol-1-yl)acetic acid
Biological Activity for Etodolac
Non-steroidal anti-inflammatory drug (NSAID) that selectively inhibits cyclooxygenase-2 (COX-2) (IC50 values are 53 and >100 μM for COX-2 and COX-1 respectively). Displays anti-inflammatory effects in both adjuvant arthritic and normal rats.
Technical Data for Etodolac
| M. Wt | 287.35 |
| Formula | C17H21NO3 |
| Storage | Store at +4°C |
| CAS Number | 41340-25-4 |
| PubChem ID | 3308 |
| InChI Key | NNYBQONXHNTVIJ-UHFFFAOYSA-N |
| Smiles | CCC1(CC(O)=O)OCCC3=C1NC2=C(CC)C=CC=C23 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Etodolac
References for Etodolac
References are publications that support the biological activity of the product.
Kato et al (2001) Cyclooxygenase-1 and cyclooxygenase-2 selectivity of non-steroidal anti-inflammatory drugs: investigation using human peripheral monocytes. J.Pharm.Pharmacol. 53 1679 PMID: 11804398
Tachibana et al (2003) Anti-inflammatory effect and low ulcerogenic activity of etodolac, a cyclooxygenase-2 selective non-steroidal anti-inflammatory drug, on adjuvant-induced arthritis in rats. Pharmacology 68 96 PMID: 12711837
Shi et al (2004) Pharmacokinetic difference between S-(+)- and R-(-)-etodolac in rats. Acta Pharmacol.Sinica 25 996
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Keywords: Etodolac, Etodolac supplier, selective, cyclooxygenase-2, COX-2, inhibitors, inhibits, oxygenases, oxidases, nonsteroidal, anti-inflammatory, drug, NSAID, Cyclooxygenase, 3871, Tocris Bioscience
⚠ WARNING: This product can expose you to chemicals including Etodolac, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov
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Literature in this Area
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