Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit Reviewexo-IWR 1
Discontinued Product
3947 has been discontinued.
Description: Negative control for endo-IWR 1 (Cat. No. 3532)
Chemical Name: 4-[(3aR,4R,7S,7aS-rel)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide
Purity: ≥99% (HPLC)
Biological Activity for exo-IWR 1
exo-IWR 1 is a negative control for endo-IWR 1 25-fold less active than endo-IWR 1; exhibits decreased activity against the Wnt/β-catenin pathway.
Active Analog also available.
Technical Data for exo-IWR 1
| M. Wt | 409.44 |
| Formula | C25H19N3O3 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 1127442-87-8 |
| PubChem ID | 1163034 |
| InChI Key | ZGSXEXBYLJIOGF-BTYSMDAFSA-N |
| Smiles | O=C(NC5=CC=CC6=C5N=CC=C6)C(C=C4)=CC=C4N2C([C@@]1([H])[C@@H](C3)C=C[C@@H]3[C@]([H])1C2=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for exo-IWR 1
References for exo-IWR 1
References are publications that support the biological activity of the product.
Lu et al (2009) Structure-activity relationship studies of small-molecule inhibitors of Wnt response. Bioorg.Med.Chem.Lett. 19 3825 PMID: 19410457
Chen et al (2008) Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nature Chem.Biol. 5 100
View Related Products by Target
Keywords: exo-IWR 1, exo-IWR 1 supplier, endo-IWR, 1, endo-IWR1, negative, controls, Wnt, beta-catenin, b-catenin, β-catenin, Beta-catenin, 3947, Tocris Bioscience
Citations for exo-IWR 1
Citations are publications that use Tocris products.
Currently there are no citations for exo-IWR 1.
Reviews for exo-IWR 1
There are currently no reviews for this product. Be the first to review exo-IWR 1 and earn rewards!
Have you used exo-IWR 1?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Pathways for exo-IWR 1
