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FC 11

Cat. No. 7306 Submit a Review Datasheet / COA / SDS
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Description: Highly potent focal adhesion kinase (FAK) Degrader (PROTAC®)
Chemical Name: 1-[2-[2-[2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]-N-[4-[[4-[[[2-[methyl(methylsulfonyl)amino]-3-pyridinyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]phenyl]-1H-1,2,3-triazole-4-carboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for FC 11

FC 11 is a highly potent focal adhesion kinase (FAK) PROTAC® Degrader (DC50 values are 40 to 370 pM depending on cell line), which is composed of the FAK inhibitor PF 562217 joined by a linker to the cereblon-binding ligand Pomalidomide (Cat. No. 6302). The effects of FC 11 are reversible upon compound wash out. FC 11 also degrades autophosphorylated FAK (pFAKtyr397), displaying near complete degradation after 3 hours at 100 nM in TM3 cells.

FAK antibodies validated for Simple Western™ (automated Western) instruments and Western Blot also available: Catalog # AF4467 and MAB4467.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data for FC 11

M. Wt 949.92
Formula C41H42F3N13O9S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2271035-37-9
PubChem ID 154723926
InChI Key RZKZQCHSKWKOAJ-UHFFFAOYSA-N
Smiles CN(S(C)(=O)=O)C1=C(C=CC=N1)CNC2=NC(NC3=CC=C(C=C3)NC(C4=CN(N=N4)CCOCCOCCNC5=C6C(N(C(C6=CC=C5)=O)C7CCC(NC7=O)=O)=O)=O)=NC=C2C(F)(F)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for FC 11

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 94.99 100

Preparing Stock Solutions for FC 11

The following data is based on the product molecular weight 949.92. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.05 mL 5.26 mL 10.53 mL
5 mM 0.21 mL 1.05 mL 2.11 mL
10 mM 0.11 mL 0.53 mL 1.05 mL
50 mM 0.02 mL 0.11 mL 0.21 mL

Molarity Calculator

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Reconstitution Calculator

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References for FC 11

References are publications that support the biological activity of the product.

Gao et al (2019) Design, synthesis, and evaluation of highly potent FAK-targeting PROTACs. ACS.Med.Chem.Lett. 11 1855 PMID: 33062164

If you know of a relevant reference for FC 11, please let us know.

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Citations for FC 11

Citations are publications that use Tocris products.

Currently there are no citations for FC 11. Do you know of a great paper that uses FC 11 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Assays for Protein Degradation
  • Induced Proximity Tools
Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia