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Description: Enhances iPSC-derived hepatocyte differentiation and maturation
Alternative Names: NSC 12407,BRD-K4477
Chemical Name: N,N'-(Methylenedi-4,1-phenylene)bis-acetamide
Purity: ≥99% (HPLC)
Biological Activity for FH 1
FH 1 enhances differentiation of induced pluripotent stem cells (iPSCs) to hepatocytes; also promotes the maturation of iPSC-derived hepatocytes.
Compound Libraries for FH 1
FH 1 is also offered as part of the Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.
Technical Data for FH 1
| M. Wt | 282.34 |
| Formula | C17H18N2O2 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 2719-05-3 |
| PubChem ID | 94990 |
| InChI Key | OEXMNSOPAKOPEF-UHFFFAOYSA-N |
| Smiles | CC(NC1=CC=C(CC2=CC=C(NC(C)=O)C=C2)C=C1)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for FH 1
References for FH 1
References are publications that support the biological activity of the product.
Shan et al (2013) Identification of small molecules for human hepatocyte expansion and iPS differentiation. Nat.Chem.Biol. 9 514 PMID: 23728495
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Citations for FH 1
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Currently there are no citations for FH 1.
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Literature in this Area
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Stem Cell Research Product Guide
This product guide provides a background to the use of small molecules in stem cell research and lists over 200 products for use in:
- Self-renewal and Maintenance
- Differentiation
- Reprogramming
- Organoid Generation
- GMP and Ancillary Material Grade Products
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Stem Cell Workflow Poster
Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.
Stem Cells Poster
Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.