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Description: Sterile-filtered 10 mM solution of LDN 193189 pre-dissolved in water
Chemical Name: 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride
Purity: ≥97% (HPLC)
Biological Activity for LDN 193189 in solution
LDN 193189 in solution is a convenient and ready-to-use 10 mM sterile-filtered solution of LDN 193189 pre-dissolved in water. A potent and selective ALK2 and ALK3 inhibitor (IC50 values are 5 nM and 30 nM, respectively); inhibits BMP4-mediated Smad1/5/8 activation. Promotes neural induction of hPSCs in combination with SB 431542 (Cat. No. 1614). Also induces differentiation of hPSCs into nociceptive sensory neurons in combination with SB 431542 (Cat. No. 1614), SU 5402 (Cat. No. 3300), CHIR 99021 (Cat. No. 4423) and DAPT (Cat. No. 2634).
Licensing Information
Sold for research purposes under exclusive agreement from The Brigham and Women's Hospital Inc. US patents 8,507,501 and 9,045,484
Technical Data for LDN 193189 in solution
| M. Wt | 479.41 |
| Formula | C25H22N6.2HCl |
| Storage | Store at -20°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 1435934-00-1 |
| InChI Key | CMQXLLAILGGLRV-UHFFFAOYSA-N |
| Smiles | N1(C2=CC=C(C3=CN4N=CC(C5=CC=NC6=C5C=CC=C6)=C4N=C3)C=C2)CCNCC1.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for LDN 193189 in solution
| Solubility | Soluble in water (supplied pre-dissolved at a concentration of 10mM) |
Product Datasheets for LDN 193189 in solution
References for LDN 193189 in solution
References are publications that support the biological activity of the product.
Yu et al (2008) BMP type I receptor inhibition reduces heterotopic ossification. Nat.Med. 14 1363 PMID: 19029982
Chambers et al (2012) Combined small-molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors. Nat.Biotechnol. 30 705 PMID: 22750882
Cuny et al (2008) Structure-activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors. Bioorg.Med.Chem.Lett. 18 4388 PMID: 18621530
Li et al (2013) Chemical approaches to stem cell biology and therapeutics. Cell Stem Cell 13 270 PMID: 24012368
Lancaster et al (2015) Generation of cerebral organoids from human pluripotent stem cells. Nat.Protoc. 9 2329 PMID: 25188634
If you know of a relevant reference for LDN 193189 in solution, please let us know.
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Stem Cell Research Product Guide
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Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
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Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.
Stem Cells Poster
Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.
Pathways for LDN 193189 in solution
