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Description: Cyclooxygenase-2 (COX-2) inhibitor
Chemical Name: N-[4-Acetyl-2-(2,4-difluorophenoxy)phenyl]methanesulfonamide
Purity: ≥98% (HPLC)
Biological Activity for FK 3311
FK 3311 is a cyclooxygenase-2 (COX-2) inhibitor. Inhibits zymosan-induced prostaglandin E2 production by rat peritoneal neutrophils in vitro and adjuvant-induced arthritis in vivo. Anti-inflammatory.
Technical Data for FK 3311
| M. Wt | 341.33 |
| Formula | C15H13F2NO4S |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 116686-15-8 |
| PubChem ID | 164009 |
| InChI Key | DIIYLGZNZGPXRR-UHFFFAOYSA-N |
| Smiles | FC1=CC(F)=CC=C1OC2=C(NS(=O)(C)=O)C=CC(C(C)=O)=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for FK 3311
References for FK 3311
References are publications that support the biological activity of the product.
Tsuji et al (1992) Studies on antiinflammatory agents. I. Synthesis and pharmacological properties of 2'-phenoxy-methanesulfonanilide derivatives. Chem.Pharm.Bull. 40 2399 PMID: 1446362
Otani et al (2007) Effects of the COX-2 inhibitor FK3311 on ischemia-reperfusion injury in the rat lung. J.Invest.Surg. 20 175 PMID: 17613692
Nakamura et al (1993) Studies on antiinflammatory agents. III. Synthesis and pharmacological properties of metabolites of 4'-acetyl-2'-(2,4-difluorophenoxy)methanesulfonanilide (FK3311). Chem.Pharm.Bull. 41
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Keywords: FK 3311, FK 3311 supplier, Cyclooxygenase-2, COX-2, inhibitors, inhibits, Oxygenases, Oxidases, FK3311, Cyclooxygenase, 2776, Tocris Bioscience
Citations for FK 3311
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Currently there are no citations for FK 3311.
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