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FK 866

Cat. No. 8072 1 Review Submit a Review Datasheet / COA / SDS
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Description: Potent and non-competitive NAMPT inhibitor; induces apoptosis and autophagy
Chemical Name: (2E)-N-[4-(1-Benzoyl-4-piperidinyl)butyl]-3-(3-pyridinyl)-2-propenamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews (1)
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for FK 866

FK 866 is a non-competitive and high-affinity inhibitor of NAMPT (nicotinamide phosphoribosyltransferase, PBEF1) (Ki = 0.3 nM); inhibits NAD biosynthesis. Induces delayed cell death by apoptosis in HepG2 human liver carcinoma cells (IC50 ~1 nM). Induces apoptosis in four different neuroblastoma cell lines; also induces autophagy in SH-SY5Y cells. Potentiates the cytotoxic effects induced by Etoposide (Cat. No. 1226) and Cisplatin (Cat. No. 2251).

Technical Data for FK 866

M. Wt 391.51
Formula C24H29N3O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 658084-64-1
PubChem ID 6914657
InChI Key KPBNHDGDUADAGP-VAWYXSNFSA-N
Smiles C(=O)(N1CCC(CCCCNC(/C=C/C=2C=CC=NC2)=O)CC1)C3=CC=CC=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for FK 866

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.15 100
ethanol 39.15 100

Preparing Stock Solutions for FK 866

The following data is based on the product molecular weight 391.51. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.55 mL 12.77 mL 25.54 mL
5 mM 0.51 mL 2.55 mL 5.11 mL
10 mM 0.26 mL 1.28 mL 2.55 mL
50 mM 0.05 mL 0.26 mL 0.51 mL

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References for FK 866

References are publications that support the biological activity of the product.

Hasmann et al (2003) FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis. Cancer Res. 63 7436 PMID: 14612543

Travelli et al (2011) Reciprocal potentiation of the antitumoral activities of FK866, an inhibitor of nicotinamide phosphoribosyltransferase, and etop. or cisp. in neuroblastoma cells. J.Pharmacol.Exp.Ther. 338 829 PMID: 21685314

Galli et al (2008) Synthesis and biological evaluation of isosteric analogues of FK866, an inhibitor of NAD salvage. Chem.Med.Chem. 3 771 PMID: 18247435

If you know of a relevant reference for FK 866, please let us know.

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Keywords: FK 866, FK 866 supplier, FK866, Nicotinamide, phosphoribosyltransferase, NMPRTase, inhibitors, inhibits, autophagy, apoptosis, NAD, NAMPT, potent, non-competitive, Apoptosis, Inducers, Autophagy, 8072, Tocris Bioscience

Citations for FK 866

Citations are publications that use Tocris products.

Currently there are no citations for FK 866. Do you know of a great paper that uses FK 866 from Tocris? Please let us know.

Reviews for FK 866

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FK 866.
By Anonymous on 12/19/2023
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: RBE and HepG2

I used FK 866 in 10–50 nM concentrations for 24-72 hours and noted significant differences in cellular NAD level and cell growth.

Treat this drug for 72 hours for best results.

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Literature in this Area

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