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Flecainide acetate

Cat. No. 1470 1 Citation Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Cardiac Na+ channel blocker. Antiarrhythmic
Chemical Name: N-(2-Piperidylmethyl)-2,5-bis-(2,2,2-trifluoroethoxy)benzamide acetate
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Flecainide acetate

Flecainide acetate is an open Na+ channel blocker that inhibits fast Na+ current in cardiac muscle in a use- and concentration-dependent manner. Orally-active class Ic antiarrhythmic agent.

Compound Libraries for Flecainide acetate

Flecainide acetate is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Flecainide acetate

M. Wt 474.4
Formula C17H20F6N2O3.C2H4O2
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 54143-56-5
PubChem ID 41022
InChI Key RKXNZRPQSOPPRN-UHFFFAOYSA-N
Smiles CC(O)=O.FC(F)(F)COC1=CC=C(OCC(F)(F)F)C(=C1)C(=O)NCC1CCCCN1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Flecainide acetate

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 11.86 25
DMSO 47.44 100

Preparing Stock Solutions for Flecainide acetate

The following data is based on the product molecular weight 474.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.11 mL 10.54 mL 21.08 mL
5 mM 0.42 mL 2.11 mL 4.22 mL
10 mM 0.21 mL 1.05 mL 2.11 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets for Flecainide acetate

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for Flecainide acetate

References are publications that support the biological activity of the product.

Banitt et al (1977) Antiarrhythmics. 2. Synthesis and antiarrhythmic activity of N-(piperidylalkyl)trifluoroethoxybenzamides. J.Med.Chem. 20 821 PMID: 874956

Rouet and Ducouret (1994) Use-and concentration-dependent effects of fleca. in guinea pig right ventricular muscle. J.Cardiovasc.Pharmacol. 24 177 PMID: 7526048

Singh et al (1984) The electrophysiology and pharmacology of verapamil, flecainide, and amiodarone: correlations with clinical effects and antiarrhythmic actions. Ann.N.Y.Acad.Sci. 17 251 PMID: 6395762

If you know of a relevant reference for Flecainide acetate, please let us know.

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Keywords: Flecainide acetate, Flecainide acetate supplier, Cardiac, Na+, channel, blockers, Antiarrhythmic, Sodium, NaV, Channels, voltage-gated, voltage-dependent, Voltage-gated, 1470, Tocris Bioscience

1 Citation for Flecainide acetate

Citations are publications that use Tocris products. Selected citations for Flecainide acetate include:

Yu et al (2014) Apamin does not inhibit human cardiac Na+ current, L-type Ca2+ current or other major K+ currents. J Neurosci 9 e96691 PMID: 24798465

Do you know of a great paper that uses Flecainide acetate from Tocris? Please let us know.

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