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Submit ReviewFluticasone propionate
Description: Selective high affinity glucocorticoid receptor agonist
Chemical Name: (6α,11β,16α,17α)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)androsta-1,4-diene-17-carbothioic acid fluoromethyl ester
Purity: ≥98% (HPLC)
Biological Activity for Fluticasone propionate
Fluticasone propionate is a high affinity, selective glucocorticoid receptor agonist (Kd = 0.5 nM). Potently stimulates glucocorticoid receptor-mediated transactivation of gene expression and enhances human eosinophil apoptosis (EC50 = 3.7 nM) in vitro. Inhibits mast cell accumulation in nasal mucosa following topical administration. Lipophilic anti-inflammatory agent with low oral bioavailability. Also potentiates KV1 channels (EC50 = 37 nM).
Licensing Information
Sold for research purposes under agreement from GlaxoSmithKline
Compound Libraries for Fluticasone propionate
Fluticasone propionate is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.
Technical Data for Fluticasone propionate
| M. Wt | 500.57 |
| Formula | C25H31F3O5S |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 80474-14-2 |
| PubChem ID | 444036 |
| InChI Key | WMWTYOKRWGGJOA-CENSZEJFSA-N |
| Smiles | O=C1C=C[C@@]2(C)C([C@@H](F)C[C@]3([H])[C@@](F)2[C@@H](O)C[C@@]4(C)[C@]([H])3C[C@@H](C)[C@](C(SCF)=O)4OC(CC)=O)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Fluticasone propionate
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 25.03 | 50 |
Preparing Stock Solutions for Fluticasone propionate
The following data is based on the product molecular weight 500.57. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4 mL | 19.98 mL | 39.95 mL |
| 2.5 mM | 0.8 mL | 4 mL | 7.99 mL |
| 5 mM | 0.4 mL | 2 mL | 4 mL |
| 25 mM | 0.08 mL | 0.4 mL | 0.8 mL |
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Product Datasheets for Fluticasone propionate
References for Fluticasone propionate
References are publications that support the biological activity of the product.
Johnson (1995) The anti-inflammatory profile of flutic. propionate. Allergy 50 11 PMID: 7604948
Zhang et al (2000) Enhancement of human eosinophil apoptosis by flutic. propionate, budesonide, and beclometh. Eur.J.Pharmacol. 406 325 PMID: 11040338
Smith and Kreutner (1998) In vitro glucocorticoid receptor binding and transcriptional activation by topically active glucocorticoids. Arzneim.-Forsch. 48 956
Pan et al (2012) Potentiation of the Kv1 family K+ channel by cortisone analogues. ACS Chem.Biol. 7 1641 PMID: 22803826
If you know of a relevant reference for Fluticasone propionate, please let us know.
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Keywords: Fluticasone propionate, Fluticasone propionate supplier, Selective, high, affinity, glucocorticoid, agonists, Receptors, GlaxoSmithKline, GSK, Glucocorticoid, Receptor, Voltage-Gated, Potassium, Channels, 2007, Tocris Bioscience
⚠ WARNING: This product can expose you to chemicals including Fluticasone propionate, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov
Citations for Fluticasone propionate
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.