Home / Pharmacology / Enzymes / Kinases / Cyclin-Dependent Kinases (CDKs) / CDK5 Subfamily / CDK5 Subfamily Inhibitors / FMF-04-159-R

FMF-04-159-R

Cat. No. 7159 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent CDK14 and CDK16 inhibitor; displays reversible inhibition of CDK14
Chemical Name: N-(1-((3-(4-(Dimethylamino)butanamido)phenyl)sulfonyl)piperidin-4-yl)-4-(2,4,6-trichlorobenzamido)-1H-pyrazole-3-carboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for FMF-04-159-R

FMF-04-159-R is a potent inhibitor of CDK16 and CDK14 (IC50 values are 6 and 140 nM, respectively in kinase activity assay; IC50 = 563 nM for CDK14 in BRET assay). Also binds CDK2 (IC50 = 493 nM). Inhibition reversible upon compound wash-out. Control for FMF-04-159-2 (Cat. No. 7158).

Technical Data for FMF-04-159-R

M. Wt 685.02
Formula C28H32Cl3N7O5S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2741262-15-5
InChI Key CPSBAEQKXVXCRQ-UHFFFAOYSA-N
Smiles CN(CCCC(NC1=CC=CC(S(=O)(N2CCC(NC(C3=NNC=C3NC(C4=C(C=C(C=C4Cl)Cl)Cl)=O)=O)CC2)=O)=C1)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for FMF-04-159-R

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 68.5 100
ethanol 34.25 50

Preparing Stock Solutions for FMF-04-159-R

The following data is based on the product molecular weight 685.02. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.46 mL 7.3 mL 14.6 mL
5 mM 0.29 mL 1.46 mL 2.92 mL
10 mM 0.15 mL 0.73 mL 1.46 mL
50 mM 0.03 mL 0.15 mL 0.29 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for FMF-04-159-R

References are publications that support the biological activity of the product.

Ferguson et al (2019) Discovery of covalent CDK14 inhibitors with pan-TAIRE family specificity. Cell Chem.Biol. 26 804 PMID: 30930164

If you know of a relevant reference for FMF-04-159-R, please let us know.

View Related Products by Target

View Related Products by Product Action

View all CDK5 Subfamily Inhibitors

Keywords: FMF-04-159-R, FMF-04-159-R supplier, cyclin, dependent, kinase, Cdk, CDK, inhibitors, inhibits, CDK14, CDK16, CDK2, CDK17, CDK18, TAIRE, family, kinases, reversible, CDK5, Subfamily, 7159, Tocris Bioscience

Citations for FMF-04-159-R

Citations are publications that use Tocris products.

Currently there are no citations for FMF-04-159-R. Do you know of a great paper that uses FMF-04-159-R from Tocris? Please let us know.

Reviews for FMF-04-159-R

There are currently no reviews for this product. Be the first to review FMF-04-159-R and earn rewards!

Have you used FMF-04-159-R?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review