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Submit ReviewFSLLRY-NH2
Description: PAR2 peptide antagonist
Purity: ≥95% (HPLC)
Biological Activity for FSLLRY-NH2
FSLLRY-NH2 is a selective PAR2 peptide antagonist. Reverses taxol-induced mechanical allodynia, heat hyperalgesia and PKC activation in ICR mice. Blocks ERK activation and collagen production in isolated cardiac fibroblasts. Also reduces symptoms in a mouse model of dermatophyte-associated itch. FSLLRY-NH2 inhibits C. albicans induced inflammation in oral mucosal cells in vitro.
Technical Data for FSLLRY-NH2
| M. Wt | 796.97 |
| Formula | C39H60N10O8 |
| Sequence |
FSLLRY (Modifications: Tyr-6 = C-terminal amide) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 245329-02-6 |
| PubChem ID | 73352412 |
| InChI Key | KMSCNWHRNILNRJ-JNRWAQIZSA-N |
| Smiles | [H]N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for FSLLRY-NH2
| Solubility | Soluble to 1 mg/ml in water |
Product Datasheets for FSLLRY-NH2
References for FSLLRY-NH2
References are publications that support the biological activity of the product.
McLarty et al (2011) Tryptase/protease-activated receptor 2 interactions induce selective mitogen-activated protein kinase signaling and collagen synthesis by cardiac fibroblasts. Hypertension 58 264 PMID: 21730297
Chen et al (2011) Proteinase-activated receptor 2 sensitizes transient receptor potential vanilloid 1, transient receptor potential vanilloid 4, and transient receptor potential ankyrin 1 in PacT.-induced neuropathic pain. Neuroscience 193 440 PMID: 21763756
Andoh et al (2012) Involvement of serine protease and proteinase-activated receptor 2 in dermatophyte-associated itch in mice. J.Pharmacol.Exp.Ther. 343 91 PMID: 22761302
Kumar et al (2022) Candida albicans Sap6 initiates oral mucosal inflammation via the protease activated receptor PAR2. Front.Immunol. 13 912748 PMID: 35844627
If you know of a relevant reference for FSLLRY-NH2, please let us know.
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Keywords: FSLLRY-NH2, FSLLRY-NH2 supplier, PAR2, protease, activated, receptors, selective, antagonists, Protease-Activated, Receptors, 4751, Tocris Bioscience
9 Citations for FSLLRY-NH2
Citations are publications that use Tocris products. Selected citations for FSLLRY-NH2 include:
White et al (2015) A brief exposure to tryptase or thrombin potentiates fibrocyte differentiation in the presence of serum or serum amyloid P. Cell Death Dis 194 142 PMID: 25429068
Bao et al (2014) PAR2-mediated upregulation of BDNF contributes to central sensitization in bone cancer pain. Mol Pain 10 28 PMID: 24886294
Tripathi et al (2014) Protease-activated receptor 2 (PAR2) is upregulated by Acanthamoeba plasminogen activator (aPA) and induces proinflammatory cytokine in human corneal epithelial cells. Invest Ophthalmol Vis Sci 55 3912 PMID: 24876278
Kumar et al (2022) Candida albicans Sap6 initiates oral mucosal inflammation via the protease activated receptor PAR2. Front Immunl 13 912748 PMID: 35844627
Eum et al (2014) Disruption of epithelial barrier by quorum-sensing N-3-(oxododecanoyl)-homoserine lactone is mediated by matrix metalloproteinases. Am J Physiol Gastrointest Liver Physiol 306 G992 PMID: 24742991
Xianglan et al (2019) Apolipoprotein E is a concentration-dependent pulmonary danger signal that activates the NLRP3 inflammasome and IL-1β secretion by bronchoalveolar fluid macrophages from asthmatic subjects. J Allergy Clin Immunol 144 426-441.e3 PMID: 30872118
Noskovičová et al (2018) Cub domain-containing protein 1 negatively regulates TGF-β signaling and myofibroblast differentiation. Am J Physiol Lung Cell Mol Physiol 314 L695 PMID: 29351434
Nithin D et al (2020) Polarization of protease-activated receptor 2 (PAR-2) signaling is altered during airway epithelial remodeling and deciliation. J Biol Chem 295 6721-6740 PMID: 32241907
Peng et al (2016) Calcium and adenosine triphosphate control of cellular pathology: asparaginase-induced pancreatitis elicited via protease-activated receptor 2 Phil. Trans. R. Soc. B 371 1700 PMID: 27377732
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