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Submit ReviewFTI 276
Description: Farnesyltransferase (FTase) inhibitor; antitumor
Chemical Name: N-[4-[2(R)-Amino-3-mercaptopropyl]amino-2-phenylbenzoyl]methionine trifluoroacetate salt
Purity: ≥95% (HPLC)
Biological Activity for FTI 276
Ras CAAX peptidomimetic, a selective inhibitor of farnesyltransferase (FTase) that displays > 100-fold selectivity over geranylgeranyltransferase I (GGTase I) (IC50 values are 0.5 and 50 nM respectively). Blocks growth of human lung carcinoma expressing oncogenic K-Ras in nude mice.
Technical Data for FTI 276
| M. Wt | 547.61 |
| Formula | C21H27N3O3S2.C2HF3O2 |
| Storage | Store at -80°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 1217471-51-6 |
| PubChem ID | 395753 |
| Smiles | SC[C@H](N)CNC1=CC=C(C(N[C@H]([C@](O)=O)CCSC)=O)C(C2=CC=CC=C2)=C1.FC(F)(C(O)=O)F |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for FTI 276
References for FTI 276
References are publications that support the biological activity of the product.
Sun et al (1995) Ras CAAX peptidomimetic FTI 276 selectively blocks tumour growth in nude mice of a human lung carcinoma with K-Ras mutation and p53 deletion. Cancer Res. 55 4243 PMID: 7671229
Lerner et al (1995) Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling inducing cytoplasic accumulation of inactive Ras-Raf complexes. J.Biol.Chem. 270 26802 PMID: 7592920
Lerner et al (1995) Disruption of oncogenic K-Ras4B processing and signaling by a potent geranylgeranyltransferase I inhibitor. J.Biol.Chem. 10 26770
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Keywords: FTI 276, FTI 276 supplier, Ras, CAAX, peptidomimetic, inhibitors, inhibits, farnesyltransferase, FTase, geranylgeranyltransferase, GGTase, carcinoma, K-Ras, tumour, tumor, FTI276, Protein, Prenyltransferases, Post-translational, Modifications, 2406, Tocris Bioscience
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