FTY 720

Cat. No. 6176 5 Citations Submit a Review Datasheet / COA / SDS

Pricing	Availability		Qty

Description: Potent S1P receptor agonist; also immunosuppressant

Alternative Names: Fingolimod,Gilenya

Chemical Name: 2-Amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride

Purity: ≥99% (HPLC)

Datasheet

Citations (5)

Reviews

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for FTY 720

FTY 720 is an S1P receptor agonist; undergoes phosphorylation by sphingosine kinase 2, which then binds S1P₁,₃,₄ and ₅ receptors (EC₅₀ values are 0.3 - 0.6 nM for S1P₁, ₄ and ₅ and ~3 nM for S1P₃). Immunosuppressant; sequesters lymphocytes in lymph nodes, reducing autoimmune response. Suppresses the development of EAE (an in vivo model of MS). Orally bioavailable and blood-brain barrier permeable.

Compound Libraries for FTY 720

FTY 720 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for FTY 720

M. Wt	343.93
Formula	C₁₉H₃₃NO₂.HCl
Storage	Store at -20°C
Purity	≥99% (HPLC)
CAS Number	162359-56-0
PubChem ID	107969
InChI Key	SWZTYAVBMYWFGS-UHFFFAOYSA-N
Smiles	CCCCCCCCC1=CC=C(C=C1)CCC(CO)(CO)N.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for FTY 720

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	34.39	100
	DMSO	34.39	100

Preparing Stock Solutions for FTY 720

The following data is based on the product molecular weight 343.93. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.91 mL	14.54 mL	29.08 mL
5 mM	0.58 mL	2.91 mL	5.82 mL
10 mM	0.29 mL	1.45 mL	2.91 mL
50 mM	0.06 mL	0.29 mL	0.58 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1

Volume 1

Concentration 2

Volume 2

Product Datasheets for FTY 720

Certificate of Analysis / Product Datasheet

Safety Datasheet

References for FTY 720

References are publications that support the biological activity of the product.

Hopkins et al (2011) ACS chemical neuroscience molecule spotlight on gil. (fingolimod; FTY720). ACS Chem. Neurosci. 2 116 PMID: 22778861

Brinkmann et al (2010) Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis. Nat. Rev. Drug Discov. 9 883 PMID: 21031003

Coelho et al (2007) The immunomodulator FTY720 has a direct cytoprotective effect in oligodendrocyte progenitors. J.Pharmacol.Exp.Ther. 323 626 PMID: 17726159

Shiow et al (2006) CD69 acts downstream of IF.-alpha/beta to inhibit S1P₁ and lymphocyte egress from lymphoid organs. Nature 440 540 PMID: 16525420

If you know of a relevant reference for FTY 720, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Sphingosine-1-Phosphate Receptor Agonists

Keywords: FTY 720, FTY 720 supplier, FTY720, |, Fingolimod, Gilenya, S1P, receptors, agonists, sphingosine-1-phosphate, immunosuppresent, sequesters, lymphocytes, orally, bioavailable, BBB, blood-brain, barrier, permeable, Sphingosine-1-phosphate, Receptors, Immunosuppressants, 6176, Tocris Bioscience