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Submit ReviewFumonisin B1
Description: Inhibitor of sphingosine N-acyltransferase
Chemical Name: 1,1'-[(1S,2R)-1-[(2S,4R,9R,11S,12S)-12-Amino-4,9,11-trihydroxy-2-methyltridecyl]-2-[(1R)-1-methylpentyl]-1,2-ethanediyl-1,2,3-(2R,2'R)-propanetricarboxylic acid ester.
Biological Activity for Fumonisin B1
Fumonisin B1 is a mycotoxin produced by Fusarium moniliforme. Potently inhibits sphingosine N-acyltransferase (ceramide synthase), causing an accumulation of sphingoid bases (IC50 ~ 75 nM). Also inhibits protein phosphatases; IC50 values are 80, 300, 400, 500 and 3000 μM for PP5, PP2Cα, PP2A, PP1γ2 and PP2B respectively.
Technical Data for Fumonisin B1
| M. Wt | 721.83 |
| Formula | C34H59NO15 |
| Storage | Store at +4°C |
| CAS Number | 116355-83-0 |
| PubChem ID | 2733487 |
| InChI Key | UVBUBMSSQKOIBE-DSLOAKGESA-N |
| Smiles | C[C@H](N)[C@@H](O)C[C@H](O)CCCC[C@@H](O)C[C@H](C)C[C@H](OC(C[C@H]([C@@](O)=O)CC(O)=O)=O)[C@H](OC(C[C@H]([C@@](O)=O)CC(O)=O)=O)[C@H](C)CCCC |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Fumonisin B1
References for Fumonisin B1
References are publications that support the biological activity of the product.
Merrill et al (1993) Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ. J.Biol.Chem. 268 27299 PMID: 8262970
Blazquez et al (2008) Cannabinoids inhibit glioma cell invasion by down-regulating matrix metalloproteinase-2 expression. Cancer Res. 68 1945 PMID: 18339876
Fukuda et al (1996) Inhibition of protein serine/threonine phosphatases by Fumonisin B1, a mycotoxin. Biochem.Biophys.Res.Comms. 220 160
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Keywords: Fumonisin B1, Fumonisin B1 supplier, inhibitors, inhibits, Ser/Thr, protein, phosphatases, Transferases, sphingosine, N-acyltransferase, ceramide, synthase, FumonisinB1, Protein, Phosphatases, Other, 3103, Tocris Bioscience
⚠ WARNING: This product can expose you to chemicals including Fumonisin B1, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov
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