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Submit ReviewGalanin (1-29) (rat, mouse)
Description: Non-selective galanin receptor agonist
Purity: ≥95% (HPLC)
Biological Activity for Galanin (1-29) (rat, mouse)
Galanin (1-29) (rat, mouse) is a non-selective galanin receptor agonist (Ki values are 0.98, 1.48 and 1.47 nM for GAL1, GAL2 and GAL3 respectively). Anticonvulsant; prevents the occurrence of full kindled seizures in rats.
Technical Data for Galanin (1-29) (rat, mouse)
| M. Wt | 3164.48 |
| Formula | C141H211N43O41 |
| Sequence |
GWTLNSAGYLLGPHAIDNHRSFSDKHGLT (Modification: Thr-29 = C-terminal amide) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 114547-31-8 |
| PubChem ID | 16201477 |
| InChI Key | JHQDYHHNJBOXKP-UPNHMZDKSA-N |
| Smiles | [H]NCC(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC=N1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Galanin (1-29) (rat, mouse)
| Solubility | Soluble to 1 mg/ml in water |
Product Datasheets for Galanin (1-29) (rat, mouse)
References for Galanin (1-29) (rat, mouse)
References are publications that support the biological activity of the product.
Wang et al (1997) Cloning and expression characterization of a novel galanin receptor. J.Biol.Chem. 272 51 PMID: 8995226
Mazarati et al (2006) Regulation of kindling epileptogenesis by hippocampal galanin type 1 and type 2 receptors: the effects of subtype-selective agonists and the role of G-protein-mediated signaling. J.Pharmacol.Exp.Ther. 318 700 PMID: 16699066
Branchek et al (2000) Galanin receptor subtypes. TiPS. 21 109
If you know of a relevant reference for Galanin (1-29) (rat, mouse), please let us know.
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Keywords: Galanin (1-29) (rat, mouse), Galanin (1-29) (rat, mouse) supplier, Non-Selective, galanin, receptors, agonists, GAL, GalR, Galanin, Receptors, 2696, Tocris Bioscience
5 Citations for Galanin (1-29) (rat, mouse)
Citations are publications that use Tocris products. Selected citations for Galanin (1-29) (rat, mouse) include:
Li (2017) Involvement of galanin and galanin receptor 1 in nociceptive modulation in the central nucleus of amygdala in normal and neuropathic rats. Sci Rep 7 15317 PMID: 29127424
Zhang (2017) Involvement of galanin and galanin receptor 2 in nociceptive modulation in anterior cingulatecortex of normal rats and rats with mononeuropathy. Sci Rep 7 45930 PMID: 28378856
Einstein et al (2013) Galanin-induced decreases in nucleus accumbens/striatum excitatory postsynaptic potentials and mor. conditioned place preference require both galanin receptor 1 and galanin receptor 2. Eur J Neurosci 37 1541 PMID: 23387435
Funck (2018) Dorsal hippocampal galanin modulates anxiety-like behaviours in rats. Brain Res 1687 74 PMID: 29499176
Gey et al (2016) Atf3 mutant mice show reduced axon regeneration and impaired regeneration-associated gene induction after peripheral nerve injury. Open Biol 6 PMID: 27581653
Do you know of a great paper that uses Galanin (1-29) (rat, mouse) from Tocris? Please let us know.
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