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Submit ReviewGhrelin (rat)
Description: Endogenous ghrelin receptor agonist
Purity: ≥95% (HPLC)
Biological Activity for Ghrelin (rat)
Ghrelin (rat) is an endogenous agonist peptide for the ghrelin receptor (GHS-R1a). Produced mainly by the stomach, Ghrelinstimulates release of growth hormone from the pituitary gland in vitro and in vivo, and regulates feeding, growth and energy production.
Licensing Information
This peptide is distributed under license from Dr. Kangawa
Technical Data for Ghrelin (rat)
| M. Wt | 3314.83 |
| Formula | C147H245N45O42 |
| Sequence |
GSSFLSPEHQKAQQRKESKKPPAKLQPR (Modifications: Ser-3 = Ser(n-octanoyl)) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 258338-12-4 |
| PubChem ID | 16139313 |
| InChI Key | ZVAOOKCCUBGSMI-MXAPAKLGSA-N |
| Smiles | [H]NCC(=O)N[C@@H](CO)C(=O)N[C@@H](COC(=O)CCCCCCC)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Ghrelin (rat)
| Solubility | Soluble to 1 mg/ml in water |
Product Datasheets for Ghrelin (rat)
References for Ghrelin (rat)
References are publications that support the biological activity of the product.
Inu (2001) Ghrelin: an orexigenic and somatotrophic signal from the stomach. Nat.Rev.Neurosci. 2 551 PMID: 11483998
Kojima et al (1999) Ghrelin is growth-hormone-releasing acylated peptide from stomach. Nature 402 656 PMID: 10604470
Tolle et al (2001) In vivo and in vitro effects of ghrelin/motilin-related peptide on GH secretion in the rat. Neuroendocrinology 73 54 PMID: 11174017
If you know of a relevant reference for Ghrelin (rat), please let us know.
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Keywords: Ghrelin (rat), Ghrelin (rat) supplier, Endogenous, ghrelin, receptor, agonist, GHS-R1a, Receptors, Growth, Hormone, Secretagog, Receptor, 1a, Ghrelin, acylated, 1465, Tocris Bioscience
22 Citations for Ghrelin (rat)
Citations are publications that use Tocris products. Selected citations for Ghrelin (rat) include:
Schéle et al (2017) Central administration of ghrelin induces conditioned avoidance in rodents. Eur Neuropsychopharmacol 27 809 PMID: 28647450
Tan et al (2014) Ablation of AgRP neurons impairs adaption to restricted feeding. Br J Pharmacol 3 694 PMID: 25352998
Torres-Fuentes et al (2014) Devil's Claw to suppress appetite--ghrelin receptor modulation potential of a Harpagophytum procumbens root extract. Adv Pharm Bull 9 e103118 PMID: 25068823
Schellekens et al (2013) Promiscuous dimerization of the GH secretagogue receptor (GHS-R1a) attenuates ghrelin-mediated signaling. J Biol Chem 288 181 PMID: 23161547
Srisai et al (2017) MRAP2 regulates ghrelin receptor signaling and hunger sensing. Nat Commun 8 713 PMID: 28959025
Zeng et al (2017) Acylated and unacylated ghrelin inhibit atrophy in myotubes co-cultured with colon carcinoma cells. Oncotarget 8 72872 PMID: 29069832
Burdyga et al (2010) Expression of cannabinoid CB1 receptors by vagal afferent neurons: kinetics and role in influencing neurochemical phenotype. Am J Physiol Gastrointest Liver Physiol 299 G63 PMID: 20430875
Lee et al (2016) The Anti-apoptotic Effect of Ghrelin on Restraint Stress-Induced Thymus Atrophy in Mice. Immune Network 16 242 PMID: 27574503
Taati et al (2015) Effects of Ghrelin on germ cell apoptosis and proinflammatory cytokines production in Ischemia-reperfusion of the rat testis. Nat Commun 13 85 PMID: 25999997
Bell et al (2015) Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2. Adv Pharm Bull 6 7066 PMID: 25967870
Bavil et al (2015) Ghrelin Decreases Angiogenesis, HIF-1α and VEGF Protein Levels in Chronic Hypoxia in Lung Tissue of Male Rats. PLoS One 5 315 PMID: 26504752
Aliparasti et al (2015) Ghrelin Administration Increases the Bax/Bcl-2 Gene Expression Ratio in the Heart of Chronic Hypoxic Rats. Front Behav Neurosci 5 195 PMID: 26236657
Parent et al (2015) Cholinergic and ghrelinergic receptors and KCNQ channels in the medial PFC regulate the expression of palatability. Int J Obes (Lond) 9 284 PMID: 26578914
Plasse et al (2015) Modulation of cue-induced firing of ventral tegmental area DA neurons by leptin and ghrelin. Mol Metab 39 1742 PMID: 26183405
Farkas et al (2013) Ghrelin decreases firing activity of gonadotropin-releasing hormone (GnRH) neurons in an estrous cycle and endocannabinoid signaling dependent manner. PLoS One 8 e78178 PMID: 24124622
Watterson et al (2012) Anorexigenic and orexigenic hormone modulation of mammalian target of rapamycin complex 1 activity and the regulation of hypothalamic agouti-related protein mRNA expression. Neurosignals 21 28 PMID: 22456226
May et al (2018) Activation of the rat hypothalamic supramammillary nucleus by food anticipation, food restriction or ghrelin administration. J Neuroendocrinol e12676 PMID: 30580497
Schéle et al (2016) Centrally Administered Ghrelin Acutely Influences Food Choice in Rodents. PLoS One 11 e0149456 PMID: 26925974
Howick et al (2018) A Dairy-Derived Ghrelinergic Hydrolysate Modulates Food Intake In Vivo. Int J Mol Sci 19 PMID: 30223587
Romero-Picó et al (2013) Hypothalamic κ-opioid receptor modulates the orexigenic effect of ghrelin. J Lab Autom 38 1296 PMID: 23348063
Tucci et al (2004) The cannabinoid CB1 receptor antagonist SR141716 blocks the orexigenic effects of intrahypothalamic ghrelin. Neuropsychopharmacology 143 520 PMID: 15381634
Thompson et al (2004) Ghrelin and des-octanoyl ghrelin promote adipogenesis directly in vivo by a mechanism independent of the type 1a GH secretagogue receptor. Iran J Reprod Med 145 234 PMID: 14551228
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.