Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewGR 231118
Description: Potent NPY Y1 antagonist/NPY Y4 agonist. Binds to NPFF receptors
Alternative Names: 1229U91,GW 1229
Biological Activity for GR 231118
GR 231118 is a potent neuropeptide Y (NPY) Y1 receptor antagonist (pA2 = 10 and 10.5 at rY1 and hY1, receptors respectively). Also a potent and selective NPY Y4 receptor agonist (pEC50 values are 6.0, 8.6 and 6.1 for rY2, hY4 and rY5 receptors respectively). Suppresses food intake in rats in vivo. Also has affinity for neuropeptide FF (NPFF) receptors in vitro (Ki = 43-73 nM).
Technical Data for GR 231118
| M. Wt | 2352.77 |
| Formula | C110H170N34O24 |
| Sequence |
IEPXYRLRY IEPXYRLRY* (Modifications: X = Dpr, Amide Bridge = 2 - 4*, 4 - 2*, Tyr-9 = C-terminal amide) |
| Storage | Desiccate at -20°C |
| CAS Number | 158859-98-4 |
| PubChem ID | 24868178 |
| InChI Key | RJRBRCCJETZJLT-GSICZYLSSA-N |
| Smiles | [H]N[C@@H]([C@@H](C)CC)C(=O)N[C@H]1CCC(=O)NCC(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCC(=O)NCC(NC(=O)[C@@H]2CCCN2C1=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(N)=O)NC(=O)[C@@H](N[H])[C@@H](C)CC)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for GR 231118
References for GR 231118
References are publications that support the biological activity of the product.
Ishihara et al (1998) A potent neuropeptide Y antagonist, 1229U91, suppressed spontaneous food intake in Zucker fatty rats. Am.J.Physiol. 274 R1500 PMID: 9612420
Mollereau et al (2001) Agonist and antagonist activities on human NPFF2 receptors of the NPY ligands GR231118 and BIBP3226. Br.J.Pharmacol. 133 1 PMID: 11325787
Parker et al (1998) GR231118 (1229U91) and other analogues of the C-terminus of neuropeptide Y are potent neuropeptide Y Y1 receptor antagonists and neuropeptide Y Y4 receptor agonists. Eur.J.Pharmacol. 349 97 PMID: 9669502
View Related Products by Target
Keywords: GR 231118, GR 231118 supplier, NPFF, receptor, ligands, NPY, Y1, antagonists, Y4, agonists, Neuropeptide, FF, GR231118, npffr1, npffr2, npff1, npff2, GW1229, 1229, U91, neuropeptides, 1229U91, GW, Receptors, FF/AF, 1486, Tocris Bioscience
Citations for GR 231118
Citations are publications that use Tocris products.
Currently there are no citations for GR 231118.
Reviews for GR 231118
There are currently no reviews for this product. Be the first to review GR 231118 and earn rewards!
Have you used GR 231118?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.