Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewGR 94800
Description: Potent, selective NK2 antagonist
Purity: ≥95% (HPLC)
Biological Activity for GR 94800
GR 94800 is a potent and selective tachykinin NK2 receptor antagonist (pKB values are 9.6, 6.4 and 6.0 for NK2, NK1 and NK3 receptors respectively). Active in vivo.
Licensing Information
Sold for research purposes under agreement from GlaxoSmithKline
Technical Data for GR 94800
| M. Wt | 904.08 |
| Formula | C49H61N9O8 |
| Sequence |
AAWFPPX (Modifications: Ala-1 = N-(Bz)Ala, Trp-3 = D-Trp, Pro-5 = D-Pro, X = Nle with C-terminal amide) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 141636-65-9 |
| PubChem ID | 5487475 |
| InChI Key | CWEISCOCKRHHOU-UJYVDGJVSA-N |
| Smiles | [H]N([C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N1CCC[C@@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCC)C(N)=O)C(=O)C1=CC=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for GR 94800
References for GR 94800
References are publications that support the biological activity of the product.
Matuszek et al (1998) An investigation of tachykinin NK2 receptor subtypes in the rat. Eur.J.Pharmacol. 352 103 PMID: 9718274
McElroy et al (1992) Highly potent and selective heptapeptide antagonists of the neurokinin NK-2 receptor. J.Med.Chem. 35 2582 PMID: 1321907
Zagorodnyuk et al (1995) Evidence that tachykinin NK1 and NK2 receptors mediate non-adrenergic non-cholinergic excitation and contraction in the circular muscle of guinea-pig duodenum. Br.J.Pharmacol. 115 237 PMID: 7545517
View Related Products by Target
View Related Products by Product Action
Keywords: GR 94800, GR 94800 supplier, Potent, selective, NK2, antagonists, Tachykinin, Receptors, Neurokinin, GR94800, GlaxoSmithKline, GSK, Receptor, 1667, Tocris Bioscience
Citations for GR 94800
Citations are publications that use Tocris products.
Currently there are no citations for GR 94800.
Reviews for GR 94800
There are currently no reviews for this product. Be the first to review GR 94800 and earn rewards!
Have you used GR 94800?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.