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Submit ReviewGranisetron hydrochloride
Description: 5-HT3 antagonist
Alternative Names: BRL 43694
Chemical Name: 1-Methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-1H-indazole-3-carboxamide hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for Granisetron hydrochloride
Granisetron hydrochloride is a 5-HT3 receptor antagonist that possesses potent antiemetic activity.
Technical Data for Granisetron hydrochloride
| M. Wt | 348.87 |
| Formula | C18H24N4O.HCl |
| Storage | Desiccate at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 107007-99-8 |
| PubChem ID | 65264 |
| InChI Key | QYZRTBKYBJRGJB-UHFFFAOYSA-N |
| Smiles | O=C(C3=NN(C)C4=C3C=CC=C4)NC1CC(N2C)CCCC2C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Granisetron hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 34.89 | 100 | |
| DMSO | 3.49 | 10 |
Preparing Stock Solutions for Granisetron hydrochloride
The following data is based on the product molecular weight 348.87. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.87 mL | 14.33 mL | 28.66 mL |
| 5 mM | 0.57 mL | 2.87 mL | 5.73 mL |
| 10 mM | 0.29 mL | 1.43 mL | 2.87 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.57 mL |
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Product Datasheets for Granisetron hydrochloride
References for Granisetron hydrochloride
References are publications that support the biological activity of the product.
Sanger and Nelson (1989) Selective and functional 5-hydroxytryptamine3 receptor antagonism by BRL 43694 (granisetron). Eur.J.Pharmacol. 159 113 PMID: 2540014
Plosker and Goa (1991) Granisetron. A review of its pharmacological properties and therapeutic use as an antiemetic. Drugs 42 805 PMID: 1723376
Martin et al (1998) Anti-emetic effect of ondans. and granis. after exposure to mixed neutron and gamma irradiation. Rad.Res. 149 631
If you know of a relevant reference for Granisetron hydrochloride, please let us know.
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Keywords: Granisetron hydrochloride, Granisetron hydrochloride supplier, 5-HT3, antagonists, Serotonin, Receptors, BRL43694, BRL, 43694, 2903, Tocris Bioscience
4 Citations for Granisetron hydrochloride
Citations are publications that use Tocris products. Selected citations for Granisetron hydrochloride include:
Gerhold et al (2015) Pronociceptive and Antinociceptive Effects of Bupren. in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude. J Neurosci 35 9580 PMID: 26134641
Murray et al (2011) Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors. J Neurophysiol 106 925 PMID: 21653728
Carlson and Fieber (2012) Unique ionotropic receptors for D-aspartate are a target for serotonin-induced synaptic plasticity in Aplysia californica. Comp Biochem Physiol C Toxicol Pharmacol 155 151 PMID: 21497673
Otvos et al (2015) Development of Plate Reader and On-Line Microfluidic Screening to Identify Ligands of the 5-Hydroxytryptamine Binding Protein in Venoms. Neuropharmacology 7 2336 PMID: 26114334
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.