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Submit ReviewGSA 10
Description: Smo receptor agonist
Chemical Name: 4-[[(1-Hexyl-1,2-dihydro-2-oxo-3-quinolinyl)carbonyl]amino]benzoic acid propyl ester
Purity: ≥98% (HPLC)
Biological Activity for GSA 10
GSA 10 is a smoothened (Smo) receptor agonist (EC50 = 1.2 μM). Does not recognize the classic cyclopamine (Cat. No. 1623) binding site. Does not promote Smo translocation to the primary cilium; is strongly potentiated by forskolin and cholera toxin. Displays anti-adipogenic effects in vitro, mediated by a non-canonical Hedgehog signaling pathway. Promotes differentiation of multipotent mesenchymal progenitor cells into osteoblasts.
Technical Data for GSA 10
| M. Wt | 450.53 |
| Formula | C26H30N2O5 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 300833-95-8 |
| PubChem ID | 54683103 |
| InChI Key | MDLUYYGRCGDKGL-UHFFFAOYSA-N |
| Smiles | OC(C1=CC=CC=C1N2CCCCCC)=C(C(NC3=CC=C(C(OCCC)=O)C=C3)=O)C2=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for GSA 10
References for GSA 10
References are publications that support the biological activity of the product.
Gorojankina et al (2013) Discovery, molecular and pharmacological characterization of GSA-10, a novel small-molecule positive modulator of Smoothened. Mol.Pharmacol. 83 1020 PMID: 23448715
Fleury et al (2016) Hedgehog associated to microparticles inhibits adipocyte differentiation via a non-canonical pathway. Sci.Rep. 24 23479 PMID: 27010359
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Keywords: GSA 10, GSA 10 supplier, GSA10, Smoothened, Smo, receptors, agonists, differentiation, multipotent, mesenchymal, progenitor, cells, osteoblasts, osteogenic, Receptors, Mesenchymal, Stem, Cells, Osteogenic, 4918, Tocris Bioscience
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