Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewGSK 789472 hydrochloride
Description: D3 antagonist. Also D2 partial agonist
Chemical Name: 4,5-Dihydro-1-phenyl-3-(2-piperidinyl)methylimidazol-2(1H)-one
Purity: ≥99% (HPLC)
Biological Activity for GSK 789472 hydrochloride
Selective dopamine D3 receptor antagonist and D2 partial agonist (pEC50 values are <5.5 and 8.3 respectively). Selective against the D4 receptor in both agonist and antagonist assays. Brain penetrant.
Technical Data for GSK 789472 hydrochloride
| M. Wt | 295.81 |
| Formula | C15H21N3O.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 1257326-24-1 |
| PubChem ID | 57347570 |
| InChI Key | BYJUVPWUMBVSTK-UHFFFAOYSA-N |
| Smiles | O=C1N(CC3CCCCN3)CCN1C2=CC=CC=C2.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for GSK 789472 hydrochloride
References for GSK 789472 hydrochloride
References are publications that support the biological activity of the product.
Holmes et al (2010) The identification of a selective DA D2 partial agonist, D3 antagonist displaying high levels of brain exposure. Bioorg.Med.Chem.Lett. 20 2013 PMID: 20153647
View Related Products by Target
View Related Products by Product Action
Keywords: GSK 789472 hydrochloride, GSK 789472 hydrochloride supplier, GSK789472, hydrochloride, dopamine, receptors, dopaminergic, D2, partial, agonists, D3, antagonists, Receptors, 3940, Tocris Bioscience
Citations for GSK 789472 hydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for GSK 789472 hydrochloride.
Reviews for GSK 789472 hydrochloride
There are currently no reviews for this product. Be the first to review GSK 789472 hydrochloride and earn rewards!
Have you used GSK 789472 hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.