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Submit ReviewGSK 9027
Description: Glucocorticoid receptor agonist
Chemical Name: N-[4-[1-(4-Fluorophenyl)-1H-indazol-5-yl-3-(trifluoromethyl)phenyl]benzenesulfonamide
Purity: ≥98% (HPLC)
Biological Activity for GSK 9027
GSK 9027 is a glucocorticoid receptor agonist (pIC50 = 8). Inhibits production of the proinflammatory mediator IL-6 in vivo.
Licensing Information
Sold for research purposes under agreement from GlaxoSmithKline.
Technical Data for GSK 9027
| M. Wt | 525.52 |
| Formula | C27H19F4N3O2S |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 1229096-88-1 |
| PubChem ID | 24882669 |
| InChI Key | DXBJGDVBQPEMOB-UHFFFAOYSA-N |
| Smiles | FC(C=C3)=CC=C3N2C1=CC=C(C4=C(C(F)(F)F)C=C(NS(CC5=CC=CC=C5)(=O)=O)C=C4)C=C1C=N2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for GSK 9027
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 52.55 | 100 |
Preparing Stock Solutions for GSK 9027
The following data is based on the product molecular weight 525.52. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.9 mL | 9.51 mL | 19.03 mL |
| 5 mM | 0.38 mL | 1.9 mL | 3.81 mL |
| 10 mM | 0.19 mL | 0.95 mL | 1.9 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.38 mL |
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Product Datasheets for GSK 9027
References for GSK 9027
References are publications that support the biological activity of the product.
Yates et al (2010) Structure guided design of 5-arylindazole glucocorticoid receptor agonists and antagonists. J.Med.Chem. 53 4531 PMID: 20469868
If you know of a relevant reference for GSK 9027, please let us know.
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Citations for GSK 9027
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.