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Submit ReviewGSK J5
Discontinued Product
This product has been withdrawn from sale and is superseded by GSK J5 HCl (Cat. No. 6935)
Description: Inactive isomer of GSK J4 (Cat. No. 4594); cell permeable
Chemical Name: N-[2-(3-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine ethyl ester
Purity: ≥98% (HPLC)
Biological Activity for GSK J5
Inactive isomer of GSK J4; also cell permeable ester derivative of the inactive control, GSK J2.
Active Analog also available.
Licensing Information
This compound is supplied in conjunction with the Structural Genomics Consortium. For further characterization details of GSK J5, a cell permeable inactive isomer of GSK J1, please visit the GSK J1 probe summary on the SGC website.
Technical Data for GSK J5
| M. Wt | 417.5 |
| Formula | C24H27N5O2 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 1394854-51-3 |
| PubChem ID | 78243729 |
| InChI Key | LQPGVGSKBNXQDU-UHFFFAOYSA-N |
| Smiles | O=C(CCNC1=NC(C2=CC=CN=C2)=NC(N3CCC(C=CC=C4)=C4CC3)=C1)OCC |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for GSK J5
References for GSK J5
References are publications that support the biological activity of the product.
Kruidenier et al (2012) A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature 488 404 PMID: 22842901
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Keywords: GSK J5, GSK J5 supplier, GSKJ5, histone, demethylases, inhibitors, inhibits, UTX, JMJD3, KDM6, H3K27, epigenetics, Histone, Demethylases, 4689, Tocris Bioscience
2 Citations for GSK J5
Citations are publications that use Tocris products. Selected citations for GSK J5 include:
Bayo et al (2018) Jumonji Inhibitors Overcome Radioresistance in Cancer through Changes in H3K4 Methylation at Double-Strand Breaks. Cell Rep 25 1040 PMID: 30355483
Carey et al (2015) Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells. Int J Nanomedicine 518 413 PMID: 25487152
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.