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Submit ReviewGW 2580
Description: Selective cFMS kinase inhibitor; orally bioavailable
Chemical Name: 5-[[3-Methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]-2,4-pyrimidinediamine
Purity: ≥99% (HPLC)
Biological Activity for GW 2580
GW 2580 is a potent and selective cFMS kinase inhibitor (IC50 = 0.06 μM). Exhibits selectivity for cFMS kinase over 186 other kinases. Inhibits CSF-1-induced growth of rat monocytes in vitro. Also inhibits bone resorption in osteoclast cultures, as well as connective tissue and bone destruction in a rat adjuvant arthritis model. Suppresses M-NFS-60 tumor cell growth in mice. Orally bioavailable.
Technical Data for GW 2580
| M. Wt | 366.41 |
| Formula | C20H22N4O3 |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 870483-87-7 |
| PubChem ID | 11617559 |
| InChI Key | MYQAUKPBNJWPIE-UHFFFAOYSA-N |
| Smiles | NC1=C(CC2=CC(OC)=C(OCC3=CC=C(OC)C=C3)C=C2)C=NC(N)=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for GW 2580
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 18.32 | 50 |
Preparing Stock Solutions for GW 2580
The following data is based on the product molecular weight 366.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 5.46 mL | 27.29 mL | 54.58 mL |
| 2.5 mM | 1.09 mL | 5.46 mL | 10.92 mL |
| 5 mM | 0.55 mL | 2.73 mL | 5.46 mL |
| 25 mM | 0.11 mL | 0.55 mL | 1.09 mL |
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Product Datasheets for GW 2580
References for GW 2580
References are publications that support the biological activity of the product.
Conway et al (2005) Inhibition of colony-stimulating-factor-1 signaling in vivo with the orally bioavailable cFMS kinase inhibitor GW2580. Proc.Natl.Acad.Sci.U.S.A. 102 16078 PMID: 16249345
Conway et al (2008) Effects of the cFMS kinase inhibitor 5-(3-methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine (GW2580) in normal and arthritic rats. J.Pharmacol.Exp.Ther. 326 41 PMID: 18434589
If you know of a relevant reference for GW 2580, please let us know.
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Keywords: GW 2580, GW 2580 supplier, GW2580, cFMS, kinase, inhibitors, inhibits, CSF-1, colony-stimulating, factor, osteoclasts, arthritis, selective, orally, bioavailable, Other, RTKs, 5673, Tocris Bioscience
1 Citation for GW 2580
Citations are publications that use Tocris products. Selected citations for GW 2580 include:
Seung-Jae et al (2018) Airway Epithelial Cell-Derived Colony Stimulating Factor-1 Promotes Allergen Sensitization. Immunity 49 275-287.e5 PMID: 30054206
Do you know of a great paper that uses GW 2580 from Tocris? Please let us know.
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