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Submit ReviewGW 501516
Description: Potent and selective PPARδ agonist
Chemical Name: 2-[2-Methyl-4-[[[4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]methyl]thio]phenoxy]acetic acid
Purity: ≥98% (HPLC)
Biological Activity for GW 501516
GW 501516 is a potent and selective PPARδ agonist (EC50 = 1.2 nM). Displays <1000-fold selectivity over other PPAR subtypes. Increases ABC A1 transporter expression and induces apolipoprotein A1-mediated cholesterol efflux in vitro. Also increase serum HDL cholesterol and lowers small, dense LDL levels in obesity in vivo models.
Technical Data for GW 501516
| M. Wt | 453.5 |
| Formula | C21H18F3NO3S2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 317318-70-0 |
| PubChem ID | 9803963 |
| InChI Key | YDBLKRPLXZNVNB-UHFFFAOYSA-N |
| Smiles | CC1=CC(SCC2=C(C)N=C(C3=CC=C(C(F)(F)F)C=C3)S2)=CC=C1OCC(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for GW 501516
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 45.35 | 100 | |
| ethanol | 22.68 | 50 |
Preparing Stock Solutions for GW 501516
The following data is based on the product molecular weight 453.5. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.21 mL | 11.03 mL | 22.05 mL |
| 5 mM | 0.44 mL | 2.21 mL | 4.41 mL |
| 10 mM | 0.22 mL | 1.1 mL | 2.21 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
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Product Datasheets for GW 501516
References for GW 501516
References are publications that support the biological activity of the product.
Oliver et al (2001) A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport. Proc.Natl.Acad.Sci.USA. 98 5306 PMID: 11309497
Ito et al (2016) Self-renewal of a purified Tie2+ hematopoietic stem cell population relies on mitochondrial clearance. Science 354 1156 PMID: 27738012
If you know of a relevant reference for GW 501516, please let us know.
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Keywords: GW 501516, GW 501516 supplier, GW501516, Potent, selective, PPARδ, agonists, agonism, reverse, cholesterol, transporter, ATP-binding, cassette, A1, obesity, peroxisome, proliferator-activated, receptors, delta, PPARdelta, Receptors, 5674, Tocris Bioscience
1 Citation for GW 501516
Citations are publications that use Tocris products. Selected citations for GW 501516 include:
Guo et al (2018) Antagonism of PPAR-γ signaling expands human hematopoietic stem and progenitor cells by enhancing glycolysis. Nat Med 24 360 PMID: 29377004
Do you know of a great paper that uses GW 501516 from Tocris? Please let us know.
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