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Submit ReviewGW 542573X
Description: Selective KCa2.1 (SK) channel activator
Chemical Name: 4-[[[[(2-Methoxyphenyl)amino]carbonyl]oxy]methyl]-piperidinecarboxylic acid-1,1-dimethylethyl ester
Purity: ≥99% (HPLC)
Biological Activity for GW 542573X
GW 542573X is an activator of small-conductance Ca2+-activated K+ channels (KCa2); selective for KCa2.1 (EC50 = 8.2 μM in HEK293 cells expressing hKCa2.1) with the profile hKCa2.1 > hKCa2.2 = hKCa2.3 > hKCa3.1 (IK).
Compound Libraries for GW 542573X
GW 542573X is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for GW 542573X
| M. Wt | 364.44 |
| Formula | C19H28N2O5 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 660846-41-3 |
| PubChem ID | 24885053 |
| InChI Key | SAXGSDIZIYFNKD-UHFFFAOYSA-N |
| Smiles | O=C(OC(C)(C)C)N1CCC(COC(NC2=CC=CC=C2OC)=O)CC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for GW 542573X
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 36.44 | 100 | |
| ethanol | 36.44 | 100 |
Preparing Stock Solutions for GW 542573X
The following data is based on the product molecular weight 364.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.74 mL | 13.72 mL | 27.44 mL |
| 5 mM | 0.55 mL | 2.74 mL | 5.49 mL |
| 10 mM | 0.27 mL | 1.37 mL | 2.74 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.55 mL |
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Product Datasheets for GW 542573X
References for GW 542573X
References are publications that support the biological activity of the product.
Hougaard et al (2009) Selective activation of the SK1 subtype of human small-conductance Ca2+-activated K+ channels by 4-(2-methyoxy-phenylcarbamoyloxymethyl)-piperidine-1-carboxylic acid tert-butyl ester (GW542573X) is dependent on serine 298 in Mol.Pharmacol. 76 569 PMID: 19515965
If you know of a relevant reference for GW 542573X, please let us know.
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Citations for GW 542573X
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