Home / Pharmacology / Enzyme-Linked Receptors / Receptor Tyrosine Kinases (RTKs) / EGFR / EGFR Inhibitors / GW 583340 dihydrochloride

GW 583340 dihydrochloride

Cat. No. 2239 1 Citation Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent dual EGFR/ErbB2 inhibitor; orally active
Chemical Name: N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[2-[[[2-(methylsulfonyl)ethyl]amino]methyl]-4-thiazolyl]-4-quinazolinamine dihydrochloride
Purity: ≥97% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for GW 583340 dihydrochloride

GW 583340 dihydrochloride is a potent dual EGFR/ErbB2 tyrosine kinase inhibitor (IC50 values are 0.01 and 0.014 μM respectively). Selectively inhibits growth of human tumor cells overexpressing EGFR and ErbB2 (IC50 values are 0.11 μM for inhibition of HN5, N87 and BT474 tumor cell lines vs. > 30 μM for inhibition of non-tumor cell line HFF). Inhibits tumor growth in vivo by ~ 80% in a murine xenograft model following oral administration.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline.

Compound Libraries for GW 583340 dihydrochloride

GW 583340 dihydrochloride is also offered as part of the Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for GW 583340 dihydrochloride

M. Wt 671.03
Formula C28H25ClFN5O3S2.2HCl
Storage Desiccate at +4°C
Purity ≥97% (HPLC)
CAS Number 1173023-85-2
PubChem ID 16219404
InChI Key WIMITXDBYLKRKB-UHFFFAOYSA-N
Smiles Cl.Cl.CS(=O)(=O)CCNCC1=NC(=CS1)C1=CC=C2N=CN=C(NC3=CC=C(OCC4=CC=CC(F)=C4)C(Cl)=C3)C2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for GW 583340 dihydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 67.1 100 with gentle warming

Preparing Stock Solutions for GW 583340 dihydrochloride

The following data is based on the product molecular weight 671.03. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.49 mL 7.45 mL 14.9 mL
5 mM 0.3 mL 1.49 mL 2.98 mL
10 mM 0.15 mL 0.75 mL 1.49 mL
50 mM 0.03 mL 0.15 mL 0.3 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets for GW 583340 dihydrochloride

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References for GW 583340 dihydrochloride

References are publications that support the biological activity of the product.

Gaul et al (2003) Discovery and biological evaluation of potent dual ErbB-2/EGFR tyrosine kinase inhibitors: 6-thiazolylquinazolines. Bioorg.Med.Chem.Lett. 13 637 PMID: 12639547

If you know of a relevant reference for GW 583340 dihydrochloride, please let us know.

View Related Products by Target

View Related Products by Product Action

View all EGFR Inhibitors

Keywords: GW 583340 dihydrochloride, GW 583340 dihydrochloride supplier, Potent, dual, EGFR, ErbB2, inhibitors, inhibits, orally, active, Epidermal, Growth, Factors, Receptors, Her, Receptor, Tyrosine, Kinases, RTKs, GW583340, dihydrochloride, GlaxoSmithKline, GSK, 2239, Tocris Bioscience

1 Citation for GW 583340 dihydrochloride

Citations are publications that use Tocris products. Selected citations for GW 583340 dihydrochloride include:

Sodani et al (2012) GW583340 and GW2974, human EGFR and HER-2 inhibitors, reverse ABCG2- and ABCB1-mediated drug resistance. Biochem Pharmacol 83 1613 PMID: 22414725

Do you know of a great paper that uses GW 583340 dihydrochloride from Tocris? Please let us know.

Reviews for GW 583340 dihydrochloride

There are currently no reviews for this product. Be the first to review GW 583340 dihydrochloride and earn rewards!

Have you used GW 583340 dihydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Angiogenesis in Cancer Poster

Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.