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GW 9508

Cat. No. 2649 3 Citations Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent and selective FFA1 (GPR40) agonist
Chemical Name: 4-[[(3-Phenoxyphenyl)methyl]amino]benzenepropanoic acid
Purity: ≥99% (HPLC)
Datasheet
Citations (3)
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for GW 9508

GW 9508 is a potent and selective agonist for the free fatty acid receptor FFA1 (GPR40) (pEC50 values are 7.32, < 4.3 and < 4.3 for FFA1, FFA2 and FFA3 receptors respectively). Inactive against a range of other GPCRs, kinases, proteases, integrins and PPARs. Potentiates glucose-stimulated insulin secretion in MIN6 cells (pEC50 = 6.14).

Licensing Information

Sold with the permission of GlaxoSmithKline

Compound Libraries for GW 9508

GW 9508 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for GW 9508

M. Wt 347.41
Formula C22H21NO3
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 885101-89-3
PubChem ID 11595431
InChI Key DGENZVKCTGIDRZ-UHFFFAOYSA-N
Smiles OC(=O)CCC1=CC=C(NCC2=CC=CC(OC3=CC=CC=C3)=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for GW 9508

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 34.74 100
ethanol 34.74 100

Preparing Stock Solutions for GW 9508

The following data is based on the product molecular weight 347.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.88 mL 14.39 mL 28.78 mL
5 mM 0.58 mL 2.88 mL 5.76 mL
10 mM 0.29 mL 1.44 mL 2.88 mL
50 mM 0.06 mL 0.29 mL 0.58 mL

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References for GW 9508

References are publications that support the biological activity of the product.

Garrido et al (2006) Synthesis and activity of small molecule GPR40 agonists. Bioorg.Med.Chem.Lett. 16 1840 PMID: 16439116

Briscoe et al (2006) Pharmacological regulation of Ins secretion in MIN6 cells through fatty acid receptor GPR40: identification of agonist and antagonist small molecules. Br.J.Pharmacol. 148 619 PMID: 16702987

Zhao and Chen (2008) Activation of ATP-sensitive potassium channels in rat pancreatic β-cells by linoleic acid through both intracellular metabolites and membrane receptor signalling pathway. J.Endocrinol. 198 533 PMID: 18550787

If you know of a relevant reference for GW 9508, please let us know.

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Keywords: GW 9508, GW 9508 supplier, Potent, selective, FFA1, GPR40, agonists, Receptors, Free, Fatty, Acid, GW9508, GlaxoSmithKline, GSK, 2649, Tocris Bioscience

3 Citations for GW 9508

Citations are publications that use Tocris products. Selected citations for GW 9508 include:

Dragano (2017) Polyunsaturated fatty acid receptors, GPR40 and GPR120, are expressed in the hypothalamus and control energy homeostasis and inflammation. J Neuroinflammation 14 91 PMID: 28446241

Watson et al (2012) Differential signaling by splice variants of the human free fatty acid receptor GPR120. Mol Pharmacol 81 631 PMID: 22282525

Oh et al (2010) GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and Ins-sensitizing effects. Cell 142 687 PMID: 20813258

Do you know of a great paper that uses GW 9508 from Tocris? Please let us know.

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