Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewGX 201
Description: Potent and selective Nav1.7 blocker; analgesic
Chemical Name: 4-[[1-[[2-Chloro-5-(trifluoromethyl)phenyl]methyl]-4-piperidinyl]methoxy]-5-cyclopropyl-2-fluoro-N-(methylsulfonyl)benzamide
Purity: ≥98% (HPLC)
Biological Activity for GX 201
GX 201 is a potent and selective Nav1.7 blocker (IC50 = 3.2 nM). Exhibits 10x selectivity for Nav1.7 over Nav1.1, Nav1.2, and Nav1.6 channels. Displays prolonged residency time on the Nav1.7 channel. Chronic dosing increases compound potency ~10-fold and provides efficacy that persists after the compound has cleared from plasma. Suppresses neuropathic pain in a mouse diabetic neuropathy model. Analgesic.
Compound Libraries for GX 201
GX 201 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for GX 201
| M. Wt | 563 |
| Formula | C25H27ClF4N2O4S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1788071-27-1 |
| PubChem ID | 118120545 |
| InChI Key | KYBPOTYVFWNSGS-UHFFFAOYSA-N |
| Smiles | CS(=O)(NC(C1=CC(C2CC2)=C(C=C1F)OCC3CCN(CC3)CC4=CC(C(F)(F)F)=CC=C4Cl)=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for GX 201
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 56.3 | 100 |
Preparing Stock Solutions for GX 201
The following data is based on the product molecular weight 563. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.78 mL | 8.88 mL | 17.76 mL |
| 5 mM | 0.36 mL | 1.78 mL | 3.55 mL |
| 10 mM | 0.18 mL | 0.89 mL | 1.78 mL |
| 50 mM | 0.04 mL | 0.18 mL | 0.36 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for GX 201
References for GX 201
References are publications that support the biological activity of the product.
Shields et al (2018) Insensitivity to pain upon adult-onset deletion of NaV1.7 or its blockade with selective inhibitors J.Neurosci. 38 10180 PMID: 30301756
Banker et al (2018) Selective NaV1.7 antagonists with long residence time show improved efficacy against inflammatory and neuropathic pain. Cell Rep. 24 3133 PMID: 30231997
If you know of a relevant reference for GX 201, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: GX 201, GX 201 supplier, GX201, Potent, selective, Nav1.7, voltage-gated, Sodium, NaV, Channels, blockers, blocks, inhibitors, inhibits, neuropathic, pain, slow, dissociation, Voltage-gated, 7029, Tocris Bioscience
Citations for GX 201
Citations are publications that use Tocris products.
Currently there are no citations for GX 201. Do you know of a great paper that uses GX 201 from Tocris? Please let us know.
Reviews for GX 201
There are currently no reviews for this product. Be the first to review GX 201 and earn rewards!
Have you used GX 201?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image