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Submit ReviewHexylHIBO
Discontinued Product
1749 has been discontinued.
View all Glutamate (Metabotropic) Group I Receptors products.
Description: Group I mGlu antagonist
Alternative Names: Hexylhomoibotenic acid
Chemical Name: α-Amino-4-hexyl-2,3-dihydro-3-oxo-5-isoxazolepropanoic acid
Purity: ≥98% (HPLC)
Biological Activity for HexylHIBO
HexylHIBO is a group I mGlu receptor antagonist (Ki values are 140 and 110 μM at mGlu1a and mGlu5a receptors respectively). Decreases sEPSCs in rat pyramidal neurons in vitro.
S-enantiomer also available.
Technical Data for HexylHIBO
| M. Wt | 256.3 |
| Formula | C12H20N2O4 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 334887-43-3 |
| PubChem ID | 3984764 |
| InChI Key | OKJBLHIYOWSQDJ-UHFFFAOYSA-N |
| Smiles | OC1=NOC(CC(C(O)=O)N)=C1CCCCCC |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for HexylHIBO
Safety Datasheet is currently unavailable on-line.
Please contact Customer Service.
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References for HexylHIBO
References are publications that support the biological activity of the product.
Bandrowski et al (2003) Baseline glutamate levels affect group I and II mGluRs in layer V pyramidal neurons of rat sensorimotor cortex. J.Neurophysiol. 89 1308 PMID: 12626613
Madsen et al (2001) Synthesis and pharmacology of 3-isoxazolol amino acids as selective antagonists at group I metabotropic glutamic acid receptors. J.Med.Chem. 44 1051 PMID: 11297452
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Keywords: HexylHIBO, HexylHIBO supplier, Group, I, mGlur, antagonists, Receptors, mGlu1, mGluR1, mGlu5, mGluR5, Glutamate, Metabotropic, Hexylhomoibotenic, acid, (Metabotropic), 1749, Tocris Bioscience
Citations for HexylHIBO
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Currently there are no citations for HexylHIBO.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
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