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Submit ReviewHMR 1556
Description: Potent and selective Iks channel blocker
Chemical Name: N-[(3R,4S)-3,4-Dihydro-3-hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)-2H-1-benzopyran-4-yl]-N-methylmetanesulfonamide
Purity: ≥98% (HPLC)
Biological Activity for HMR 1556
HMR 1556 is a potent and selective Iks channel blocker (IC50 values are 10.5 and 34 nM in canine and guinea pig ventricular myocytes respectively). Selectively inhibits IKs currents over IKr, IKI, Ito and L-type Ca2+ channel currents. Also has little or no effect on Kv11.1 Kv1.5, Kv1.3, Kir2.1 and HCN2 channel currents. Potentiates E-4031-induced arrhythmias in vivo.
Compound Libraries for HMR 1556
HMR 1556 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for HMR 1556
| M. Wt | 411.44 |
| Formula | C17H24F3NO5S |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 223749-46-0 |
| PubChem ID | 9887834 |
| InChI Key | SRZRLJWUQFIZRH-LSDHHAIUSA-N |
| Smiles | CC2(C)[C@H](O)[C@@H](N(S(C)(=O)=O)C)C1=CC(OCCCC(F)(F)F)=CC=C1O2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for HMR 1556
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 41.14 | 100 |
Preparing Stock Solutions for HMR 1556
The following data is based on the product molecular weight 411.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.43 mL | 12.15 mL | 24.3 mL |
| 5 mM | 0.49 mL | 2.43 mL | 4.86 mL |
| 10 mM | 0.24 mL | 1.22 mL | 2.43 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.49 mL |
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Product Datasheets for HMR 1556
References for HMR 1556
References are publications that support the biological activity of the product.
Gerlach et al (2001) Synthesis and activity of novel and selective I(Ks)-channel blockers. J.Med.Chem. 44 3831 PMID: 11689069
Michael et al (2007) Potentiation of E-4031-induced torsade de pointes by HMR1556 or ATX-II is not predicted by action potential short-term variability or triangulation. Br.J.Pharmacol 152 1215 PMID: 17965747
Thomas et al (2003) HMR 1556, a potent and selective blocker of slowly activating delayed rectifier potassium current. J.Cardiovasc.Pharmacol. 41 140 PMID: 12500032
If you know of a relevant reference for HMR 1556, please let us know.
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Keywords: HMR 1556, HMR 1556 supplier, HMR1556, potent, selective, IKs, channels, blockers, blocks, cardiac, Kv7.1, potassium, K+, slow, delayed, rectifier, current, KCNQ1, voltage-gated, voltage-dependent, Voltage-Gated, Potassium, Channels, 5011, Tocris Bioscience
Citations for HMR 1556
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Reviews for HMR 1556
Average Rating: 5 (Based on 1 Review.)
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HMR 1556 shortens cardiac action potential duration.
By
Anonymous on 05/16/2019
Assay Type: In Vitro
Species: Other
Cell Line/Tissue: Cardiomyocytes
A representative action potential of a guinea pig cardiomyocyte before and after superfusion with 500 nM HMR 1556 for 5 min and stimulated at a frequency of 1 Hz in a whole cell patch clamp model. HMR 1556 significantly shortened action potential duration of guinea pig ventricular cardiomyocytes.
