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Submit ReviewHOE 140
Description: Potent and selective B2 antagonist
Alternative Names: Icatibant
Purity: ≥95% (HPLC)
Biological Activity for HOE 140
HOE 140 is a potent and selective bradykinin B2 receptor antagonist (pA2 = 9.04). Also inhibits aminopeptidase N (Ki = 9.1 μM).
Technical Data for HOE 140
| M. Wt | 1304.52 |
| Formula | C59H89N19O13S |
| Sequence |
RRPXGXSXXR (Modifications: Arg-1 = D-Arg, X-4 = Hyp, X-6 = Thi, X-8 = D-Tic, X-9 = Oic) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 130308-48-4 |
| PubChem ID | 90488794 |
| InChI Key | QURWXBZNHXJZBE-JNFYKTHFSA-N |
| Smiles | [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@H](CC1=CC=CS1)C(=O)N[C@@H](CO)C(=O)N1CC2=C(C[C@@H]1C(=O)N1C3CCCCC3C[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C=CC=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for HOE 140
| Solubility | Soluble to 1 mg/ml in water |
Product Datasheets for HOE 140
References for HOE 140
References are publications that support the biological activity of the product.
Hock et al (1991) Hoe 140 a new potent and long acting bradykinin-antagonist: in vitro studies. Br.J.Pharmacol. 102 769 PMID: 1364851
Feletou et al (1994) Agonistic and antagonistic properties of the bradykinin B2 receptor antagonist, Hoe 140, in isolated blood vessels from different species. Br.J.Pharmacol. 112 683 PMID: 8075888
Bawolak et al (2006) The bradykinin B2 receptor antagonist icatibant (Hoe 140) blocks aminopeptidase N at micromolar concentrations: off-target alterations of signaling mediated by the bradykinin B1 and angiotensin receptors. Eur.J.Pharmacol. 551 108 PMID: 17026984
If you know of a relevant reference for HOE 140, please let us know.
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Keywords: HOE 140, HOE 140 supplier, Potent, selective, B2, antagonists, Receptors, Bradykinin, HOE140, Icatibant, 3014, Tocris Bioscience
5 Citations for HOE 140
Citations are publications that use Tocris products. Selected citations for HOE 140 include:
Raffai et al (2016) Angiotensin-(1-7) selectively induces relaxation and modulates endothelium-dependent dilation in mesenteric arteries of salt-fed rats Journal of Vascular Research 53 105 PMID: 27676088
Xu et al (2014) Nicotine exaggerates LPS-induced airway hyperreactivity via JNK-mediated up-regulation of Toll-like receptor 4. Am J Respir Cell Mol Biol 51 370 PMID: 24669857
Kawaguchi et al (2015) Functional expression of bradykinin B1 and B2 receptors in neonatal rat trigeminal ganglion neurons. Oncogene 9 229 PMID: 26124706
Brailoiu (2017) Modulation of cardiac vagal tone by bradykinin acting on nucleus ambiguus. Neuroscience 365 23 PMID: 28951324
Zhou et al (2019) Serum bradykinin levels as a diagnostic marker in cervical cancer with a potential mechanism to promote VEGF expression via BDKRB2. Int J Oncol 55 131 PMID: 31059006
Do you know of a great paper that uses HOE 140 from Tocris? Please let us know.
Reviews for HOE 140
Average Rating: 4 (Based on 1 Review.)
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works good.
By
Anonymous on 05/13/2020
Assay Type: In Vitro
Species: Rat
Cell Line/Tissue: neurons
B2 receptor blocker HOE140, 200 nM
treat 20 min
