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Submit ReviewIberiotoxin
Description: KCa (BK) channel blocker
Purity: ≥95% (HPLC)
Biological Activity for Iberiotoxin
Iberiotoxin is a selective blocker of the big conductance Ca2+-activated K+ channel.
Technical Data for Iberiotoxin
| M. Wt | 4230 |
| Formula | C179H274N50O55S7 |
| Sequence |
XFTDVDCSVSKECWSVCKDLFGVDRGKCMGKKCRCYQ (Modifications: X-1 = pGlu, Disulfide bridges: 7-28, 13-33, 17-35) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 129203-60-7 |
| PubChem ID | 16132435 |
| InChI Key | VDNVVLOBNHIMQA-UHFFFAOYSA-N |
| Smiles | [H]N1[C@@H](CCC1=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CO)NC1=O)C(C)C)C(=O)N[C@@H](CC1=CNC4=C1C=CC=C4)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(=O)N3)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCSC)NC2=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCC(N)=O)C(O)=O)C(C)C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Iberiotoxin
| Solubility | Soluble to 0.70 mg/ml in water |
Product Datasheets for Iberiotoxin
References for Iberiotoxin
References are publications that support the biological activity of the product.
Galvez et al (1990) Purification and characterization of a unique, potent, peptidyl probe for the high conductance calcium-activated potassium channel from venom of the scorpion Buthus tamulus. J.Biol.Chem. 265 11083 PMID: 1694175
Suarez-Kurtz et al (1991) Effects of charybdotoxin and iberiotoxin on the spontaneous motility and tonus of different guinea-pig smooth muscle tissues. J.Pharmacol.Exp.Ther. 259 439 PMID: 1717682
If you know of a relevant reference for Iberiotoxin, please let us know.
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Keywords: Iberiotoxin, Iberiotoxin supplier, K+, channel, blockers, high, conductance, Ca2+-dependent, Potassium, KCa, Channels, ca2+-activated, ca2+-dependent, venoms, Ca2+-Activated, 1086, Tocris Bioscience
15 Citations for Iberiotoxin
Citations are publications that use Tocris products. Selected citations for Iberiotoxin include:
Lai et al (2014) BK channels regulate sinoatrial node firing rate and cardiac pacing in vivo. Am J Physiol Heart Circ Physiol 307 H1327 PMID: 25172903
Needham et al (2014) The role of K+ and Cl- channels in the regulation of retinal arteriolar tone and blood flow. FASEB J 55 2157 PMID: 24609622
Mannowetz et al (2013) Slo1 is the principal potassium channel of human spermatozoa. Elife (Cambridge) 2 e01009 PMID: 24137539
Grassin-Delyle et al (2013) The expression and relaxant effect of bitter taste receptors in human bronchi. Respir Res 14 134 PMID: 24266887
Lee et al (2011) Role of perivascular adipose tissue-derived methyl palmitate in vascular tone regulation and pathogenesis of hypertension. Circulation 124 1160 PMID: 21844078
Pulkkinen et al (2012) The bitter taste receptor (TAS2R) agonists denatonium and chloroquine display distinct patterns of relaxation of the guinea pig trachea. Am J Physiol Lung Cell Mol Physiol 303 L956 PMID: 22962016
Townsend and Emala (2013) Quercetin acutely relaxes airway smooth muscle and potentiates β-agonist-induced relaxation via dual phosphodiesterase inhibition of PLCβ and PDE4. Am J Physiol Lung Cell Mol Physiol 305 L396 PMID: 23873842
Hirono et al (2015) BK Channels Localize to the Paranodal Junction and Regulate Action Potentials in Myelinated Axons of Cerebellar Purkinje Cells. Am J Physiol Cell Physiol 35 7082 PMID: 25948259
Shukla et al (2014) Maternal nutrient restriction during pregnancy impairs an endothelium-derived hyperpolarizing factor-like pathway in sheep fetal coronary arteries. Am J Physiol Heart Circ Physiol 307 H134 PMID: 24816259
Ok et al (2014) Bupivacaine-induced Vasodilation Is Mediated by Decreased Calcium Sensitization in Isolated Endothelium-denuded Rat Aortas Precontracted with Phenylephrine. Korean J Pain 27 229 PMID: 25031808
Wan et al (2013) Reduced vascular smooth muscle BK channel current underlies heart failure-induced vasoconstriction in mice. Mol Pain 27 1859 PMID: 23325318
Kyle et al (2013) Mechanisms underlying activation of transient BK current in rabbit urethral smooth muscle cells and its modulation by IP3-generating agonists. Invest Ophthalmol Vis Sci 305 C609 PMID: 23804200
Zemkova et al (2011) NE causes a biphasic change in mammalian pinealocye membrane potential: role of alpha1B-adrenoreceptors, phospholipase C, and Ca2+. Endocrinology 152 3842 PMID: 21828176
Benvindo et al (2011) Relaxant effect and possible mechanism of 17-nor-subincanadine E in rabbit corpora cavernosa. Asian J Androl 13 747 PMID: 21765439
Tahvildari et al (2008) Ionic basis of ON and OFF persistent activity in layer III lateral entorhinal cortical principal neurons. J Neurophysiol 99 2006 PMID: 18256167
Do you know of a great paper that uses Iberiotoxin from Tocris? Please let us know.
Reviews for Iberiotoxin
Average Rating: 5 (Based on 1 Review.)
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Selective blocker worked ideally to block Calcium channels.
By
Farzana Islam on 10/02/2018
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: HEK 293
High-affinity and specific KCa1.1 channel blocker, used to study how it works to block SK channels. The product dissolved in aqueous buffer and was excellent in the lab conditions. Inhibition of SK channels were observed.
