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Submit ReviewIloprost
Description: Prostacyclin (PGI2) analog
Alternative Names: ZK 36374
Chemical Name: (5E)-5-[(3aS,4R,5R,6aS)-Hexahydro-5-hydroxy-4-[(1E,3S)-3-hydroxy-4-methyl-1-octen-6-ynyl]-2(1H)-pentalenylidene]pentanoic acid
Purity: ≥97% (HPLC)
Biological Activity for Iloprost
Iloprost is a prostacyclin (PGI2) analog that binds with high affinity to IP, EP1 and EP3 receptors (Ki values are 11, 11, 56, 284, 619, 1035, 1870 and 6487 nM for IP, EP1, EP3, EP4, FP, DP, EP2 and TP receptors respectively). Inhibits platelet aggregation induced by collagen, thrombin and ADP (IC50 values are 0.24, 0.71 and 1.07 nM respectively).
Technical Data for Iloprost
| M. Wt | 360.49 |
| Formula | C22H32O4 |
| Storage | Store at -20°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 78919-13-8 |
| PubChem ID | 5311181 |
| InChI Key | HIFJCPQKFCZDDL-ACWOEMLNSA-N |
| Smiles | O[C@@H]1C[C@H]2[C@H](C/C(C2)=C/CCCC(O)=O)[C@H]1/C=C/[C@@H](O)C(C)CC#CC |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Iloprost
References for Iloprost
References are publications that support the biological activity of the product.
Della Bella et al (2001) Novel mode of action of iloprost: in vitro down-regulaton of endothelial cell adhesion molecules. Prostaglandins Other Lipid Mediat. 65 73 PMID: 11403500
Abramovitz et al (2000) The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim.Biophys.Acta 1483 285 PMID: 10634944
Schror et al (1981) The antiplatelet and cardiovascular actions of a new carbacyclin derivative (ZK 36 374) - equipotent to PGI2 in vitro. Naunyn-Schmied.Arch.Pharmacol. 316 252
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Keywords: Iloprost, Iloprost supplier, Prostacyclin, PGI2, IP, EP1, EP3, Receptors, Prostaglandin, Prostanoid, prostaglandins, prostacyclins, eicosanoids, ZK36374, ZK, 36374, 2038, Tocris Bioscience
2 Citations for Iloprost
Citations are publications that use Tocris products. Selected citations for Iloprost include:
Lee and Diamond (2015) A human platelet calcium calculator trained by pairwise agonist scanning. Nat Commun 11 e1004118 PMID: 25723389
Flamm et al (2012) Multiscale prediction of patient-specific platelet function under flow. Blood 120 190 PMID: 22517902
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