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Submit ReviewIndomethacin
Description: Cyclooxygenase inhibitor (COX-1 > COX-2)
Chemical Name: 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole
Purity: ≥98% (HPLC)
Biological Activity for Indomethacin
Indomethacin is a cyclooxgenase (COX) inhibitor; displays selectivity for COX-1 (IC50 values are 230 and 630 nM for human COX-1 and COX-2 respectively). Widely used anti-inflammatory agent. Identified by chemoinformatics as targeting human host proteins that interact with SARS-CoV-2.
Technical Data for Indomethacin
| M. Wt | 357.79 |
| Formula | C19H16ClNO4 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 53-86-1 |
| PubChem ID | 3715 |
| InChI Key | CGIGDMFJXJATDK-UHFFFAOYSA-N |
| Smiles | COC1=CC=C2N(C(=O)C3=CC=C(Cl)C=C3)C(C)=C(CC(O)=O)C2=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Indomethacin
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| ethanol | 17.89 | 50 with gentle warming | |
| DMSO | 35.78 | 100 |
Preparing Stock Solutions for Indomethacin
The following data is based on the product molecular weight 357.79. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.79 mL | 13.97 mL | 27.95 mL |
| 5 mM | 0.56 mL | 2.79 mL | 5.59 mL |
| 10 mM | 0.28 mL | 1.4 mL | 2.79 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.56 mL |
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Product Datasheets for Indomethacin
References for Indomethacin
References are publications that support the biological activity of the product.
Palomer et al (2002) Identification of novel cyclooxygenase-2 selective inhibitors using pharmacophore models. J.Med.Chem. 45 1402 PMID: 11906281
Shen and Winter (1977) Chemical and biological studies on indomethacin, sul. and their analogs. Adv.Drug Res. 12 90 PMID: 343530
Walters and Willoughby (1965) Indomethacin, a new anti-inflammatory drug: its potential use as a laboratory tool. J.Pathol.Bacteriol. 90 641 PMID: 5849618
Gordon et al (2020) A SARS-CoV-2-human protein-protein interaction map reveals drug targets and potential drug-repurposing. Nature 583 PMID: 32353859
If you know of a relevant reference for Indomethacin, please let us know.
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Keywords: Indomethacin, Indomethacin supplier, Cyclooxygenase, inhibitors, inhibits, COX-1, COX-2, Oxygenases, Oxidases, COVID-19, SARS-CoV-2, severe, acute, respiratory, syndrome, Coronavirus, 1708, Tocris Bioscience
6 Citations for Indomethacin
Citations are publications that use Tocris products. Selected citations for Indomethacin include:
Allen et al (2015) DNA Damage Response Proteins and Oxygen Modulate Prostaglandin E2 Growth Factor Release in Response to Low and High LET Ionizing Radiation. Front Oncol 5 260 PMID: 26697402
Miller et al (2012) CCR2 chemokine receptor signaling mediates pain in experimental osteoarthritis. Proc Natl Acad Sci U S A 109 20602 PMID: 23185004
Flamm et al (2012) Multiscale prediction of patient-specific platelet function under flow. Blood 120 190 PMID: 22517902
Tang et al (2014) Lactate-mediated glia-neuronal signalling in the mammalian brain. Nat Commun 5 3284 PMID: 24518663
Cramer et al (2015) Abnormal excitability and episodic low-frequency oscillations in the cerebral cortex of the tottering mouse. J Biomed Sci 35 5664 PMID: 25855180
Gonnermann et al (2015) Resistance of cyclooxygenase-2 expressing pancreatic ductal adenocarcinoma cells against γδ T cell cytotoxicity. Oncoimmunology 4 e988460 PMID: 25949900
Do you know of a great paper that uses Indomethacin from Tocris? Please let us know.
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Literature in this Area
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