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Description: JNK inhibitor; anti-inflammatory; also NO donor
Chemical Name: 11H-Indeno[1,2-b]quinoxalin-11-one oxime sodium salt
Purity: ≥99% (HPLC)
Biological Activity for IQ 1S
JNK inhibitor (Kd values are 87, 360 and 390 nM for JNK3, JNK2 and JNK1, respectively). Inhibits LPS-induced proinflammatory cytokine and nitric oxide production in vitro. Attenuates collagen-induced arthritis severity and inhibits murine delayed-type hypersensitivity in vivo. Anti-inflammatory and immunosuppressive. Also releases NO upon metabolism by liver microsomes.
Technical Data for IQ 1S
| M. Wt | 269.23 |
| Formula | C15H8N3NaO |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 1421610-21-0 |
| PubChem ID | 72193876 |
| InChI Key | JBNHEGDICQSOLR-NYAKATHWSA-M |
| Smiles | [Na]O/N=C1C2=NC3=CC=CC=C3N=C2C4=C\1C=CC=C4 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for IQ 1S
References for IQ 1S
References are publications that support the biological activity of the product.
Schepetkin et al (2015) Anti-Inflammatory effects and joint protection in collagen-induced arthritis after treatment with IQ-1S, a selective c-Jun N-terminal kinase Inhibitor. J.Pharmacol.Exp.Ther. 353 505 PMID: 25784649
Schepetkin et al (2012) Identification and characterization of a novel class of c-Jun N-terminal kinase inhibitors. Mol.Pharmacol. 81 832 PMID: 22434859
Atochin et al (2016) A novel dual NO-donating oxime and c-Jun N-terminal kinase inhibitor protects against cerebral ischemia-reperfusion injury in mice. Neurosci.Lett. 618 45 PMID: 26923672
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Keywords: IQ 1S, IQ 1S supplier, IQ1S, JNK, inhibitors, inhibits, anti-inflammatory, immunosuppresents, NO, donor, JNK/c-jun, ROS, Donors, 5575, Tocris Bioscience
Citations for IQ 1S
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Currently there are no citations for IQ 1S.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
MAPK Signaling Scientific Review
MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.
Pathways for IQ 1S
