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Submit ReviewIschemin sodium salt
Description: CBP inhibitor; cell permeable
Chemical Name: 5-[(1E)-2-(2-Amino-4-hydroxy-5-methylphenyl)diazenyl]-2,4-dimethylbenzenesulfonic acid sodium salt
Purity: ≥99% (HPLC)
Biological Activity for Ischemin sodium salt
Ischemin sodium salt is a CBP bromodomain inhibitor. Inhibits p53 interaction with CBP and decreases p53 transcriptional activity. Protects against Doxorubicin-induced apoptosis in cardiomyocytes in vitro. Cell permeable.
Technical Data for Ischemin sodium salt
| M. Wt | 357.36 |
| Formula | C15H16N3O4SNa |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| PubChem ID | 64983 |
| InChI Key | XWNMORIHKRROGW-UHFFFAOYSA-N |
| Smiles | CC1=CC(/N=N/C2=C(C)C=C(C)C(S(=O)(O[Na])=O)=C2)=C(N)C=C1O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Ischemin sodium salt
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 35.74 | 100 | |
| DMSO | 35.74 | 100 |
Preparing Stock Solutions for Ischemin sodium salt
The following data is based on the product molecular weight 357.36. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.8 mL | 13.99 mL | 27.98 mL |
| 5 mM | 0.56 mL | 2.8 mL | 5.6 mL |
| 10 mM | 0.28 mL | 1.4 mL | 2.8 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.56 mL |
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Product Datasheets for Ischemin sodium salt
References for Ischemin sodium salt
References are publications that support the biological activity of the product.
Borah et al (2011) A small molecule binding to the coactivator CREB-binding protein blocks apoptosis in cardiomyocytes. Chem.Biol. 18 531 PMID: 21513889
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Keywords: Ischemin sodium salt, Ischemin sodium salt supplier, CBP, bromodomain, inhibitors, inhibits, p53, interaction, cell, permeable, 1357059, 00, 7, Bromodomains, 4695, Tocris Bioscience
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