Home / Pharmacology / Enzymes / Transferases / PORCN / PORCN Inhibitors / IWP 12

IWP 12

Cat. No. 5279 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent PORCN inhibitor; active in vivo
Chemical Name: N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-3,6-dimethyl-4-oxothieno[3,2-d]pyrimidin-2-yl)thio]acetamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for IWP 12

IWP 12 is a potent inhibitor of Porcupine (PORCN), a membrane-bound O-acyltransferase (MBOAT) (IC50 = 15 nM). Inhibits Wnt/β-catenin and Wnt/planar cell polarity (PCP) signaling pathways. Blocks zebrafish tailfin regeneration in vivo.

Technical Data for IWP 12

M. Wt 418.56
Formula C18H18N4O2S3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 688353-45-9
PubChem ID 3244448
InChI Key RBFDSBJDWZOTGR-UHFFFAOYSA-N
Smiles CC(S1)CC2=C1C(N(C)C(SCC(NC3=NC(C=CC(C)=C4)=C4S3)=O)=N2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for IWP 12

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 41.86 100

Preparing Stock Solutions for IWP 12

The following data is based on the product molecular weight 418.56. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.39 mL 11.95 mL 23.89 mL
5 mM 0.48 mL 2.39 mL 4.78 mL
10 mM 0.24 mL 1.19 mL 2.39 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for IWP 12

References are publications that support the biological activity of the product.

Dodge et al (2012) Diverse chemical scaffolds support direct inhibition of the membrane-bound O-acyltransferase porcupine. J.Biol.Chem. 287 23246 PMID: 22593577

If you know of a relevant reference for IWP 12, please let us know.

View Related Products by Target

View Related Products by Product Action

View all PORCN Inhibitors

Keywords: IWP 12, IWP 12 supplier, IWP12, potent, porcupine, porcn, wnt, bcatenin, beta_catenin, βcatenin, MBOAT, membrane-bound, O-acyltransferases, PORCN, 5279, Tocris Bioscience

Citations for IWP 12

Citations are publications that use Tocris products.

Currently there are no citations for IWP 12. Do you know of a great paper that uses IWP 12 from Tocris? Please let us know.

Reviews for IWP 12

There are currently no reviews for this product. Be the first to review IWP 12 and earn rewards!

Have you used IWP 12?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review