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Submit ReviewJHW 007 hydrochloride
Description: High affinity dopamine uptake inhibitor
Chemical Name: (3-endo)-3-[Bis(4-fluorophenyl)methoxy]-8-butyl-8-azabicyclo[3.2.1]octane hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for JHW 007 hydrochloride
JHW 007 hydrochloride is a dopamine uptake inhibitor; displays high affinity for the dopamine transporter (DAT) (Ki = 25 nM compared to 1330 and 1730 for NET and SERT respectively). Suppresses the effects of cocaine administration in a dose-dependent manner and decreases cocaine and methamphetamine self-administration in rats.
Compound Libraries for JHW 007 hydrochloride
JHW 007 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for JHW 007 hydrochloride
| M. Wt | 421.95 |
| Formula | C24H29F2NO.HCl |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 202645-74-7 |
| PubChem ID | 71771746 |
| InChI Key | RHYMGBAYGRUKNZ-DHWZJIOFSA-N |
| Smiles | [H][C@@]12CC[C@@](C[C@H](OC(C4=CC=C(F)C=C4)C3=CC=C(F)C=C3)C2)([H])N1CCCC.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for JHW 007 hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 42.19 | 100 | |
| ethanol | 42.19 | 100 |
Preparing Stock Solutions for JHW 007 hydrochloride
The following data is based on the product molecular weight 421.95. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.37 mL | 11.85 mL | 23.7 mL |
| 5 mM | 0.47 mL | 2.37 mL | 4.74 mL |
| 10 mM | 0.24 mL | 1.18 mL | 2.37 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.47 mL |
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Product Datasheets for JHW 007 hydrochloride
References for JHW 007 hydrochloride
References are publications that support the biological activity of the product.
Kristensen et al (2011) SLC6 neurotransmitter transporters: structure, function, and regulation. Pharmacol.Rev. 63 585 PMID: 21752877
Kopajtic et al (2010) DA transporter-dependent and -independent striatal binding of the benztr. analog JHW 007, a cocaine antagonist with low abuse liability. J.Pharmacol.Exp.Ther. 335 703 PMID: 20855444
Velaquez-Sanchez et al (2010) The high affinity DA uptake inhibitor, JHW 007, blocks cocaine-induced reward, locomotor stimulation and sensitization. Eur.Neuropsychopharmacol. 20 501 PMID: 20413276
Hiranita et al (2014) Preclinical efficacy of N-substituted benztr. analogs as antagonists of metha. self-administration in rats. J.Pharmacol.Exp.Ther. 348 174 PMID: 24194527
If you know of a relevant reference for JHW 007 hydrochloride, please let us know.
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Keywords: JHW 007 hydrochloride, JHW 007 hydrochloride supplier, JHW007, dopamine, uptake, inhibitors, inhibits, DAT, transporter, Dopamine, Transporters, 4351, Tocris Bioscience
1 Citation for JHW 007 hydrochloride
Citations are publications that use Tocris products. Selected citations for JHW 007 hydrochloride include:
Andersen et al (2015) Binding site residues control inhibitor selectivity in the human NE transporter but not in the human DA transporter. Stem Cell Reports 5 15650 PMID: 26503701
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
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The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
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