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Submit ReviewJIP-1 (153-163)
Description: JNK-selective inhibitor peptide
Alternative Names: TI-JIP
Biological Activity for JIP-1 (153-163)
Peptide inhibitor of c-Jun N-terminal kinase (JNK), based on residues 153-163 of JNK-interacting protein-1 (JIP-1). Binds to JNK with affinity in the micromolar range and minimally inhibits p38 and ERK.
Technical Data for JIP-1 (153-163)
| M. Wt | 1341.6 |
| Formula | C61H104N20O14 |
| Sequence |
RPKRPTTLNLF (Modifications: Phe-11 = C-terminal amide) |
| Storage | Desiccate at -20°C |
| CAS Number | 438567-88-5 |
| PubChem ID | 90479803 |
| InChI Key | BWQKOFMNXWAKES-QHYOMBHZSA-N |
| Smiles | [H]N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for JIP-1 (153-163)
References for JIP-1 (153-163)
References are publications that support the biological activity of the product.
Barr et al (2002) Identification of the critical features of a small peptide inhibitor of JNK activity. J.Biol.Chem. 277 10987 PMID: 11790767
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Keywords: JIP-1 (153-163), JIP-1 (153-163) supplier, JNK-selective, inhibitors, inhibits, peptide, c-Jun, N-Terminal, Kinase, SAPKs, Stress-Activated, Protein, MAPK, Mitogen-Activated, protein, TIJIP, TI-JIP, JNK/c-jun, 1565, Tocris Bioscience
1 Citation for JIP-1 (153-163)
Citations are publications that use Tocris products. Selected citations for JIP-1 (153-163) include:
Kumar et al (2015) The Ser/Thr kinase MAP4K4 drives c-Met-induced motility and invasiveness in a cell-based model of SHH medulloblastoma. Springerplus 4 19 PMID: 25625039
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
MAPK Signaling Scientific Review
MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.
Pathways for JIP-1 (153-163)
