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JNJ 10397049

Cat. No. 4317 2 Citations Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Selective OX2 antagonist
Chemical Name: N-(2,4-Dibromophenyl)-N'-[(4S,5S)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl]-urea
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for JNJ 10397049

JNJ 10397049 is a selective OX2 receptor antagonist (pIC50 = 7.4 for chimeric OX2 receptors; pKB values are 5.9 and 8.5 for OX1 and OX2 receptors respectively). Shows no significant activity in a panel of over 50 other neurotransmitters and neuropeptide receptors. Achieves high level of OX2 receptor occupancy in the rat brain; exhibits sleep-promoting effects in rats.

Compound Libraries for JNJ 10397049

JNJ 10397049 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for JNJ 10397049

M. Wt 484.18
Formula C19H20Br2N2O3
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 708275-58-5
PubChem ID 9869934
InChI Key RBKIJGLHFFQHBE-IRXDYDNUSA-N
Smiles O=C(N[C@@H]2[C@H](C3=CC=CC=C3)OC(C)(C)OC2)NC1=C(Br)C=C(Br)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for JNJ 10397049

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 100
ethanol 100

Preparing Stock Solutions for JNJ 10397049

The following data is based on the product molecular weight 484.18. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.07 mL 10.33 mL 20.65 mL
5 mM 0.41 mL 2.07 mL 4.13 mL
10 mM 0.21 mL 1.03 mL 2.07 mL
50 mM 0.04 mL 0.21 mL 0.41 mL

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References for JNJ 10397049

References are publications that support the biological activity of the product.

Dugovic et al (2009) Blockade of orexin-1 receptors attenuates orexin-2 receptor antagonism-induced sleep promotion in the rat. J.Pharmacol.Exp.Ther. 330 142 PMID: 19363060

Tran et al (2011) Chimeric, mutant orexin receptors show key interactions between orexin receptors, peptides and antagonists. Eur.J.Pharmacol. 667 120 PMID: 21679703

Gozzi et al (2011) Functional magnetic resonance imaging reveals different neural substrates for the effects of orexin-1 and orexin-2 receptor antagonists. PLoS ONE 6 e16406 PMID: 21307957

If you know of a relevant reference for JNJ 10397049, please let us know.

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Keywords: JNJ 10397049, JNJ 10397049 supplier, JNJ10397049, Orexins, hypocretins, receptors, antagonists, selective, OX2R, OX2, sleep, Receptor, 4317, Tocris Bioscience

2 Citations for JNJ 10397049

Citations are publications that use Tocris products. Selected citations for JNJ 10397049 include:

Lei et al (2020) The arousal effect of hyperbaric oxygen through orexin/hypocretin an upregulation on ketamine/ethanol-induced unconsciousness in male rats. J Neurosci Res 98 201-211 PMID: 30895638

Mavanji et al (2015) Promotion of Wakefulness and Energy Expenditure by Orexin-A in the Ventrolateral Preoptic Area. Sleep 38 1361 PMID: 25845696

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.