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JNJ 17203212

Cat. No. 3361 2 Citations Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Reversible, competitive and potent TRPV1 antagonist
Chemical Name: 4-[3-(Trifluoromethyl)-2-pyridinyl]-N-[5-(trifluoromethyl)-2-pyridinyl]-1-piperazinecarboxamide
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for JNJ 17203212

JNJ 17203212 is a reversible, competitive and potent TRPV1 antagonist (pKi values are 6.5, 7.1 and 7.3 at rat, guinea pig and human TRPV1 respectively). Inhibits capsaicin- and H+-induced channel activation (pIC50 values are 6.32 and 7.23 respectively) and exhibits antitussive and analgesic activity in vivo.

Compound Libraries for JNJ 17203212

JNJ 17203212 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for JNJ 17203212

M. Wt 419.32
Formula C17H15F6N5O
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 821768-06-3
PubChem ID 11339118
InChI Key JFRYYGVYCWYIDQ-UHFFFAOYSA-N
Smiles O=C(NC3=NC=C(C(F)(F)F)C=C3)N(CC2)CCN2C1=C(C(F)(F)F)C=CC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for JNJ 17203212

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 41.93 100
ethanol 41.93 100

Preparing Stock Solutions for JNJ 17203212

The following data is based on the product molecular weight 419.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.38 mL 11.92 mL 23.85 mL
5 mM 0.48 mL 2.38 mL 4.77 mL
10 mM 0.24 mL 1.19 mL 2.38 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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Keywords: JNJ 17203212, JNJ 17203212 supplier, Reversible, competitive, potent, TRPV1, antagonists, Vanillioid, Receptors, VR1, Channels, Transient, Receptor, Potential, JNJ17203212, TRPV, 3361, Tocris Bioscience

2 Citations for JNJ 17203212

Citations are publications that use Tocris products. Selected citations for JNJ 17203212 include:

Kelly et al (2015) Increased function of pronociceptive TRPV1 at the level of the joint in a rat model of osteoarthritis pain. PLoS One 74 252 PMID: 24152419

Vijayvergiya et al (2015) Measurement of Ensemble TRPV1 Ion Channel Currents Using Droplet Bilayers. PLoS One 10 e0141366 PMID: 26513481

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