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Submit ReviewJNJ 27141491
Description: Potent and selective human CCR2 antagonist
Chemical Name: 3-[(1S)-1-(3,4-Difluorophenyl)propyl]-2,3-dihydro-5-(5-isoxazolyl)-2-thioxo-1H-imidazole-4-carboxylic acid methyl ester
Purity: ≥98% (HPLC)
Biological Activity for JNJ 27141491
Potent, noncompetitive human CCR2 antagonist; inhibits MCP-1-induced Ca2+ mobilization in hCCR2-CHO cells (IC50 = 13 nM). Exhibits selectivity for CCR2 over CCR1, CCR3-8 and CXCR1-3. Delays onset and reduces neurological signs in an experimental autoimmune encephalomyelitis model of multiple sclerosis in hCCR2 knock-in mice. Orally active.
Technical Data for JNJ 27141491
| M. Wt | 379.38 |
| Formula | C17H15F2N3O3S |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 871313-59-6 |
| PubChem ID | 11703589 |
| InChI Key | SYARXICKXVXWNA-LBPRGKRZSA-N |
| Smiles | FC1=CC([C@H](CC)N2C(C(OC)=O)=C(C3=CC=NO3)NC2=S)=CC=C1F |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for JNJ 27141491
References for JNJ 27141491
References are publications that support the biological activity of the product.
Buntinx et al (2008) Pharmacological profile of JNJ-27141491 [(S)-3-[3,4-difluorophenyl)-propyl]-5-isoxazol-5-yl-2-thioxo-2,3-dihydro-1H-imidazole-4-carboxyl acid methyl ester], as a noncompetitive and orally active antagonist of the human chemokine receptor J.Pharmacol.Exp.Ther. 327 1 PMID: 18599682
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Keywords: JNJ 27141491, JNJ 27141491 supplier, JNJ27141491, Chemokine, CC, Receptors, 5176, Tocris Bioscience
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