Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewJTP 103237
Description: Potent and selective monoacyglycerol acyltransferase 2 (MOGAT2) inhibitor
Chemical Name: 7-[4,6-Bis(1,1-dimethylethyl)-2-pyrimidinyl]-5,6,7,8-tetrahydro-3-[4-(trifluoromethoxy)phenyl]-1,2,4-triazolo[4,3-a]pyrazine
Purity: ≥98% (HPLC)
Biological Activity for JTP 103237
JTP 103237 is a potent and selective monoacyglycerol acyltransferase 2 (MOGAT2) inhibitor (IC50 = 20 - 40 nM). Displays >7000-fold selectivity for human MOGAT2 over human DGAT2. Modulates intestinal lipid absorption in mice. Decreases triglyceride, diacylglycerol and fatty acid synthesis in mouse model of fatty liver. Chronic treatment decreases hepatic triglyceride content and body weight, and improves glucose tolerance in diet-induced obese mice.
Compound Libraries for JTP 103237
JTP 103237 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for JTP 103237
| M. Wt | 474.52 |
| Formula | C24H29F3N6O |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1883864-16-1 |
| PubChem ID | 91884614 |
| InChI Key | KELNXHBJTXCXSN-UHFFFAOYSA-N |
| Smiles | CC(C)(C1=CC(C(C)(C)C)=NC(N2CCN3C(C2)=NN=C3C4=CC=C(C=C4)OC(F)(F)F)=N1)C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for JTP 103237
References for JTP 103237
References are publications that support the biological activity of the product.
Okuma et al (2015) JTP-103237, a novel monoacylglycerol acyltransferase inhibitor, modulates fat absorption and prevents diet-induced obesity. Eur.J.Pharmacol. 758 72 PMID: 25857225
Okuma et al (2015) JTP-103237, a monoacylglycerol acyltransferase inhibitor, prevents fatty liver and suppresses both triglyceride synthesis and de novo lipogenesis. J.Pharmacol.Sci. 128 150 PMID: 26215699
View Related Products by Target
View Related Products by Product Action
Keywords: JTP 103237, JTP 103237 supplier, JTP103237, monoacyglycerol, acyltransferase, MGAT2, inhibitors, inhibits, potent, selective, antiobesity, triglyceride, synthesis, DGAT2L, MOGAT2, Other, Transferases, Lipid, Metabolism, 6765, Tocris Bioscience
Citations for JTP 103237
Citations are publications that use Tocris products.
Currently there are no citations for JTP 103237.
Reviews for JTP 103237
There are currently no reviews for this product. Be the first to review JTP 103237 and earn rewards!
Have you used JTP 103237?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image