JW 642

Discontinued Product

4906 has been discontinued.

View all Monoacylglycerol Lipase products.
Description: MAGL inhibitor
Chemical Name: 4-[(3-Phenoxyphenyl)methyl]-1-piperazinecarboxylic acid 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ester
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (4)

Biological Activity for JW 642

JW 642 is a potent and selective monoacylglycerol lipase (MAGL) inhibitor (IC50 = 3.7 nM). Displays >1000-fold selectivity for MAGL over fatty acid amide hydrolase (IC50 = 20.6 μM). Analog of JZL 195 (Cat. No. 4715).

Licensing Information

Sold under license from The Scripps Research Institute

Technical Data for JW 642

M. Wt 462.39
Formula C21H20F6N2O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1416133-89-5
PubChem ID 71656520
InChI Key AVSCNEOUWSVZEY-UHFFFAOYSA-N
Smiles O=C(OC(C(F)(F)F)C(F)(F)F)N(CC3)CCN3CC1=CC(OC2=CC=CC=C2)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for JW 642

References are publications that support the biological activity of the product.

Chang et al (2012) Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates. Chem.Biol. 19 579 PMID: 22542104

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Keywords: JW 642, JW 642 supplier, JW642, MAGL, monoacylglycerol, potent, selective, inhibitors, inhibits, lipases, esterases, 4906, Tocris Bioscience

Citations for JW 642

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Currently there are no citations for JW 642.

Reviews for JW 642

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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