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Submit ReviewJW 67
Description: Wnt pathway inhibitor; induces degradation of active β-catenin
Chemical Name: Trispiro[3H-indole-3,2'-[1,3]dioxane-2'',3'''-[3H]indole]-2,2'''(1H,1'''H)-dione
Purity: ≥97% (HPLC)
Biological Activity for JW 67
JW 67 is an inhibitor of canonical Wnt pathway signaling (IC50 = 1.17 μM); targets the β-catenin destruction complex (GSK-3β/AXIN/APC) to induce β-catenin degradation. Selective for the canonical Wnt pathway over the Sonic hedgehog (Shh) and NF-κB pathways. Blocks G1/S cell cycle progression in colorectal cancer (CRC) cell lines (GI50 = 7.8 μM).
Compound Libraries for JW 67
JW 67 is also offered as part of the Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.
Technical Data for JW 67
| M. Wt | 394.38 |
| Formula | C21H18N2O6 |
| Storage | Store at +4°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 442644-28-2 |
| PubChem ID | 644733 |
| InChI Key | BTXRSHKJNDFHGA-UHFFFAOYSA-N |
| Smiles | O=C1NC6=C(C=CC=C6)C21OCC3(COC(C(NC5=C4C=CC=C5)=O)4OC3)CO2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for JW 67
References for JW 67
References are publications that support the biological activity of the product.
Shultz et al (2012) [1,2,4]triazol-3-ylsulfanylmethyl)-3-phenyl-[1,2,4]oxadiazoles: antagonists of the Wnt pathway that inhibit tankyrases 1 and 2 via novel adenosine pocket binding. J.Med.Chem. 55 1127 PMID: 22260203
Waaler et al (2011) Novel synthetic antagonists of canonical Wnt signaling inhibit colorectal cancer cell growth. Cancer Res. 71 197 PMID: 21199802
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Keywords: JW 67, JW 67 supplier, JW67, canonical, Wnt, pathway, signaling, inhibitors, inhibits, beta, b, β, catenin, proliferation, selective, Other, Signaling, Beta-catenin, 4651, Tocris Bioscience
Citations for JW 67
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Currently there are no citations for JW 67.
Reviews for JW 67
Average Rating: 4 (Based on 1 Review.)
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Induces beta-Catenin degradation.
By
Anonymous on 02/10/2023
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: HepG2, and Huh,
When treated in to hepatoma cells (0.5uM) for 48 hours, it substantially induced the degradation of b catenin.
Pathways for JW 67
