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Description: Selective ATP-uncompetitive mitotic kinesin Eg5 inhibitor
Chemical Name: N-(4-Acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-thiadiazol-2-yl)acetamide
Purity: ≥99% (HPLC)
Biological Activity for K 858
K 858 is a selective ATP-uncompetitive mitotic kinesin Eg5 inhibitor (IC50 = 1.3 μM). Induces mitotic arrest, caspase-3 activation and cell growth inhibition in HCT116 cells. Displays no effect on microtubule dynamics. Preferentially induces mitotic arrest in cancer cells.
Technical Data for K 858
| M. Wt | 277.34 |
| Formula | C13H15N3O2S |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 72926-24-0 |
| PubChem ID | 2930014 |
| InChI Key | JEFVYQYZCAVNTP-UHFFFAOYSA-N |
| Smiles | CC1(C2=CC=CC=C2)N(C(C)=O)N=C(NC(C)=O)S1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for K 858
References for K 858
References are publications that support the biological activity of the product.
Nakai et al (2009) K858, a novel inhibitor of mitotic kinesin Eg5 and antitumor agent, induces cell death in cancer cells. Cancer Res. 69 3901 PMID: 19351824
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Keywords: K 858, K 858 supplier, mitotic, kinesin, Eg5, inhibitors, inhibits, cytoskeleton, motor, proteins, ATPase, K858, Kinesin, 3703, Tocris Bioscience
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Cell Cycle and DNA Damage Research Product Guide
This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:
- Cell Cycle and Mitosis
- DNA Damage Repair
- Targeted Protein Degradation
- Ubiquitin Proteasome Pathway
- Chemotherapy Targets